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 Detalle_Publicacion

Selective up-regulation of cannabinoid CB1 receptor coupling to Go-proteins in suicide victims with mood disorders

Abstract: Brain endocannabinoid system is proposed to play a role in the pathogenesis of affective disorders. In the present study, we analyzed the functionality of the cannabinoid receptor type 1 (CB1 receptor) at different transduction levels in prefrontal cortex (PFC) of depressed suicide victims. We examined stimulation of [35S]GTP?S binding, activation of G? protein subunits and inhibition of adenylyl cyclase by the cannabinoid agonist WIN55,212-2, as well as [3H]CP55,940 binding, in PFC homogenates from suicide victims with major depression (MD) and matched control subjects. CB1 receptor-stimulated [35S]GTP?S binding was significantly greater in the PFC of MD compared with matched controls (23%, p?

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Biochem Pharmacol. 2018 Nov;157:258-265

Editorial: Elsevier

 Fecha de publicación: 01/11/2018

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.bcp.2018.08.012

ISSN: 0006-2952,1873-2968

Proyecto español: SAF2007/61862 ; SAF2011-25020 ; SAF2015-67457-R ; SAF 2009- 08460

Url de la publicación: https://dx.doi.org/10.1016/j.bcp.2018.08.012

Autores/as

SUSANA MATO SANTOS

ELSA MARIA VALDIZAN RUIZ

GONZÁLEZ MAESO, JAVIER

RODRÍGUEZ PUERTAS, RAFAEL

MEANA, JAVIER

SALLÉS, JOAN