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 Detalle_Publicacion

Microenvironment Eradication of Hepatitis C: A Novel Treatment Paradigm

Abstract: OBJECTIVES: Prisons are major reservoirs of hepatitis C virus (HCV) in which a therapeutic approach has been particularly difficult so far. Our aim was to create a permanent program of HCV elimination in a prison based on a "test and treat" strategy. METHODS: This open-label clinical trial was conducted in the Spanish prison "El Dueso" between May 2016 and July 2017. Viremic patients were treated with a ledipasvir-sofosbuvir regimen (8-12 weeks) according to the 2015 Spanish Guidelines. A teleconsultation program was established to follow-up patients from the hospital. Non-responders were submitted for a phylogenetic analysis and offered retreatment. An evaluation of new cases of HCV infection was performed every 6 months and upon release in all inmates. RESULTS: 847 (99.5%) inmates accepted to participate. HCV antibodies were present in 110 (13.0%) and 86 (10.2%) had detectable viremia. Most of them were genotype 1 or 3 (82.6%) and had

 Fuente: Am J Gastroenterol. 2018 Nov;113(11):1639-1648

Editorial: Springer Nature

 Año de publicación: 2018

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s41395-018-0157-x

ISSN: 0002-9270,1572-0241

Url de la publicación: https://doi.org/10.1038/s41395-018-0157-x

Autores/as

ANTONIO CUADRADO LAVIN

SUSANA LLERENA SANTIAGO

COBO, CARMEN

PALLÁS, JOSÉ RAMÓN

MATEO, MIGUEL

JOAQUIN CABEZAS GONZALEZ

JOSE IGNACIO FORTEA ORMAECHEA

ÁLVAREZ, SILVIA

PELLÓN, RAÚL

JUAN CRESPO DEL POZO

SANTIAGO ECHEVARRIA VIERNA

MARIA ROSA AYESA ARRIOLA

Mª ESTHER SETIEN SUERO

JESUS AGÜERO BALBIN

CHUECA, NATALIA

GARCIA, FEDERICO

CALLEJA, JOSE LUIS