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Superficial radially resolved fluorescence and 3D photochemical time-dependent model for photodynamic therapy

Abstract: Photodynamic therapy (PDT) dosimetric tools are crucial for treatment planning and noninvasive monitoring by means of fluorescence. Present approaches consider usually a 1D problem, a simple photochemical process, or a spatially homogeneous photosensitizer. In this work, a radially resolved superficial photosensitizer fluorescence and 3D photochemical time-dependent PDT model are presented. The model provides a time-dependent estimation of tissue fluorescence and the photosensitizer and singlet oxygen 3D concentrations. The model is applied to a basal cell carcinoma treated by Metvix topical photosensitizer protocol. The analysis shows the potentiality in treatment planning and monitoring. The fluorescence results are in agreement with previous measurements.

 Autoría: Salas-García I., Fanjul-Vélez F., Arce-Diego J.,

 Fuente: Optics Letters, 2014, 39(7), 1845-1848

Editorial: The Optical Society (OSA)

 Año de publicación: 2014

Nº de páginas: 4

Tipo de publicación: Artículo de Revista

 DOI: 10.1364/OL.39.001845

ISSN: 0146-9592,1539-4794,1071-2763