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Superficial radially resolved fluorescence and 3D photochemical time-dependent model for photodynamic therapy

Abstract: Photodynamic therapy (PDT) dosimetric tools are crucial for treatment planning and noninvasive monitoring by means of fluorescence. Present approaches consider usually a 1D problem, a simple photochemical process, or a spatially homogeneous photosensitizer. In this work, a radially resolved superficial photosensitizer fluorescence and 3D photochemical time-dependent PDT model are presented. The model provides a time-dependent estimation of tissue fluorescence and the photosensitizer and singlet oxygen 3D concentrations. The model is applied to a basal cell carcinoma treated by Metvix topical photosensitizer protocol. The analysis shows the potentiality in treatment planning and monitoring. The fluorescence results are in agreement with previous measurements.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Salas-García I., Fanjul-Vélez F., Arce-Diego J.,

 Fuente: Optics Letters, 2014, 39(7), 1845-1848

Editorial: The Optical Society (OSA)

 Año de publicación: 2014

Nº de páginas: 4

Tipo de publicación: Artículo de Revista

 DOI: 10.1364/OL.39.001845

ISSN: 0146-9592,1539-4794,1071-2763