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Plasma prolactin levels are associated with the severity of illness in drug-naive first-episode psychosis female patients

Abstract: Patients with schizophrenia frequently present hyperprolactinemia as a consequence of antipsychotic treatment. However, an increase in circulating prolactin levels has also been shown in patients without previous treatment. Our objective was to compare prolactin levels between antipsychotic-naive first-episode psychosis (AN-FEP) patients and healthy controls (HC). As part of an FEP program (Programa Asistencial Fases Iniciales de Psicosis [PAFIP]), 270 AN-FEP patients and 153 HC were eligible for this study. Serum prolactin levels were measured by an automated immunochemiluminescent assay. Subjects' sex and having an AN-FEP diagnosis both had an effect on prolactin levels, with higher levels in women than in men, and in AN-FEP patients than in HC. Moreover, plasma prolactin levels showed a negative correlation with the SAPS scores in AN-FEP female patients. AN-FEP patients have increased levels of prolactin, which might be stress-induced. This, together with the association of higher prolactin with a lower severity of the disease, suggests that prolactin might play a neuroprotective role, especially in women.

 Fuente: Arch Womens Ment Health. 2019 Jun;22(3):367-373

Editorial: Springer

 Año de publicación: 2019

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1007/s00737-018-0899-x

ISSN: 1434-1816,1435-1102

Url de la publicación: https://doi.org/10.1007/s00737-018-0899-x

Autores/as

MANUEL DELGADO ALVARADO

DIANA TORDESILLAS GUTIERREZ

MARIA ROSA AYESA ARRIOLA

CANAL, MANUEL

VICTOR ORTIZ GARCIA DE LA FOZ

LABAD, JAVIER