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Sleep-disordered breathing is independently associated with increased aggressiveness of cutaneous melanoma: a multicenter observational study in 443 patients

Abstract: Background: Sleep-disordered breathing (SDB) has been associated with a greater incidence and mortality of cancer, although such findings are inconsistent. However, no large studies are currently available to investigate this association in patients with a specific type of cancer. This study seeks to assess potential relationships between SDB severity and aggressiveness markers of cutaneous melanoma. Methods: Four hundred and forty-three patients with a diagnosis of melanoma underwent a sleep study within 6 months of diagnosis. General demographics were collected, along with melanoma characteristics and polygraphic parameters consisting of the apnea-hypopnea index (AHI) and indices of both continuous and intermittent night-time oxyhemoglobin desaturation (DI4%). An exploration of independent relationships between SDB and various objective melanoma aggressiveness markers (Breslow index, presence of ulceration, presence of regression, mitotic index, stage of severity, damage to the sentinel lymph, and spreading of the melanoma) was performed. Results: Patients in the upper tertiles of AHI or DI4% were 1.94 (95% CI, 1.14-3.32; P = .022) and 1.93 (95% CI, 1.14-3.26; P = .013) times more likely, respectively, to present with aggressive melanoma (Breslow index > 1 mm) than those in the lowest tertiles of these sleep attributes after adjustment for age, sex, tumor location, and BMI. This association was particularly prominent among patients < 56 years of age with Breslow index > 2 mm. The presence of the additional markers of aggressiveness was also associated with higher AHI and DI4% values. Conclusions: The severity of SDB was independently associated with greater aggressiveness of cutaneous melanoma, particularly among younger patients.

 Fuente: Chest, 2018, 154(6),1348-1358

 Editorial: Elsevier

 Año de publicación: 2018

 Nº de páginas: 11

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.chest.2018.07.015

 ISSN: 0012-3692,1931-3543

 Url de la publicación: https://doi.org/10.1016/j.chest.2018.07.015

Autoría

MARTINEZ GARCIA, MIGUEL ANGEL

CAMPOS RODRIGUEZ, FRANCISCO

NAGORE, EDUARDO

MARTORELL, ANTONIO

RODRIGUEZ PERALTO, JOSE LUIS

RIVEIRO FALKENBACH, ERICA

HERNANDEZ, LUIS

BAÑULS, JOSE

ARIAS, EVA

ORTIZ, PABLO

CABRIADA, VALENTIN

GARDEAZABAL, JOSE

MONTSERRAT, JOSEP MARIA

CARRERA, CRISTINA

CORRAL, JAIME

MASA, JUAN FERNANDO

GOMEZ DETERREROS, JAVIER

ABAD, JORGE