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Hyperbaric oxygen therapy does not have a negative impact on bone signaling pathways in humans

Abstract: Introduction: Oxygen is emerging as an important factor in the local regulation of bone remodeling. Some preclinical data suggest that hyperoxia may have deleterious effects on bone cells. However, its clinical relevance is unclear. Hence, we studied the effect of hyperbaric oxygen therapy (HBOT) on serum biomarkers reflecting the status of the Wnt and receptor activator of NF-?B ligand (RANKL) pathways, two core pathways for bone homeostasis. Materials and methods: This was a prospective study of 20 patients undergoing HBOT (mean age 58 yrs., range 35?82 yrs.) because of complications of radiotherapy or chronic anal fissure. Patients were subjected to HBOT (100% oxygen; 2.4 atmospheres absolute for 90 min). The average number of HBOT sessions was 20 ± 5 (range 8?31). Serum hypoxia-inducible factor 1-? (HIF1-?), osteoprotegerin (OPG), RANKL, and the Wnt inhibitors sclerostin and dickkopf-1 (DKK1) were measured at baseline and after HBOT by using specific immunoassays. Results: HIF-1? in eight patients with measurable serum levels increased from 0.084 (0.098) ng/mL at baseline to 0.146 (0.130) ng/mL after HBOT (p = 0.028). However, HBOT did not induce any significant changes in the serum levels of OPG, RANKL, sclerostin or DKK1. This was independent of the patients? diagnosis, either neoplasia or benign. Conclusion: Despite the potential concerns about hyperoxia, we found no evidence that HBOT has any detrimental effect on bone homeostasis.

 Fuente: Healthcare, 2021, 9 (12), 1714

 Editorial: MDPI

 Fecha de publicación: 10/12/2021

 Nº de páginas: 7

 Tipo de publicación: Artículo de Revista

 DOI: 10.3390/healthcare9121714

 ISSN: 2227-9032

 Url de la publicación: https://www.mdpi.com/2227-9032/9/12/1714

Autoría

SALMÓN-GONZÁLEZ, ZAIDA

ANCHUELO, JAVIER

BORREGÁN, JUAN C.

ÁLVARO DEL REAL BOLT

MARIA CAROLINA SAÑUDO CAMPO

GARCÍA-UNZUETA, MARIA TERESA