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Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study

Abstract: Most children and adolescents infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus disease 2019 (COVID-19) that usually does not require medical intervention. However, a small proportion of pediatric patients develop a severe clinical condition, multisystem inflammatory syndrome in children (MIS-C). The involvement of epigenetics in the control of the immune response and viral activity prompted us to carry out an epigenomic study to uncover target loci regulated by DNA methylation that could be altered upon the appearance of MIS-C.

 Fuente: www.thelancet.com Vol 50 Month , 2022

 Editorial: Elsevier

 Año de publicación: 2022

 Nº de páginas: 12

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.eclinm.2022.101515

 ISSN: 0140-6736,1474-547X

 Url de la publicación: https://doi.org/10.1016/j.eclinm.2022.101515

Autoría

DÁVALOS, VERÓNICA

GARCÍA-PRIETO, CARLOS A.

FERRER, GERARDO

AGUILERA-ALBESA, SERGIO

VALENCIA-RAMOS, JUAN

RODRÍGUEZ-PALMERO, AGUSTÍ

RUIZ, MONTSERRAT

PLANAS-SERRA, LAURA

JORDÁN, IOLANDA

ALEGRÍA, IOSUNE

FLORES-PÉREZ, PATRICIA

CANTARÍN, VERÓNICA

FUMADÓ, VERÓNICA

RODRIGO, CARLOS

MÉNDEZ-HERNÁNDEZ, MARÍA

LÓPEZ-GRANADOS, EDUARDO

COLOBRAN, ROGER

RIVIÈRE, JACQUES G.

SOLER-PALACÍN, PERE