Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Biomarkers of endothelial dysfunction and atherosclerosis in hidradenitis suppurativa

Abstract: Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with an increased prevalence of subclinical atherosclerosis and cardiovascular risk. Angiopoietin-2 (Ang-2), asymmetric dimethylarginine (ADMA), and osteoprotegerin (OPG) are molecules related to endothelial dysfunction (ED) and atherosclerosis, but also to disease severity in patients with chronic inflammatory disorders. In this case-control study, we aimed to investigate serum Ang-2, ADMA, and OPG levels in patients with HS, and to assess the potential relationship between these levels and disease severity. Seventy-five patients with HS and 60 controls were assessed. Serum Ang-2, ADMA, and OPG concentrations were determined in all participants. HS patients had significantly higher Ang-2 and ADMA levels than controls after adjusting for confounders. Besides, Ang-2 concentrations positively correlated with disease severity in the adjusted multivariable analysis. Nevertheless, serum OPG levels did not significantly differ between HS patients and controls. Our results indicate that serum Ang-2 and ADMA levels are significantly increased in patients with HS. Furthermore, Ang-2 might be a suitable marker of HS severity.

 Fuente: J Dermatol . 2022 Oct;49(10):1052-1056

Editorial: Wiley-Blackwell

 Año de publicación: 2022

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/1346-8138.16484

ISSN: 0385-2407,1346-8138

Url de la publicación: https://www.doi.org/10.1111/1346-8138.16484

Autoría

OCEJO-VIÑALS, J GONZALO

LÓPEZ-SUNDH, ANA E

GUIRAL, SANDRA

RUIZ-SOLANA, MARTA

MATA, CRISTINA

PORTILLA, VIRGINIA

CORRALES, ALFONSO