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Secukinumab is effective and safe in the long-term treatment of plaque psoriasis in a daily practice setting: multicenter study in 384 spanish patients

Abstract: The aim of the study was to assess the long-term effectiveness and safety of secukinumab in Spanish patients with moderate-to-severe psoriasis in a daily practice setting. Nationwide multicenter, observational, retrospective, non-interventional, single-cohort study including patients who initiated treatment with secukinumab in daily clinical practice conditions. Subjects were followed for a minimum of 3 months and a maximum of 24 months. Psoriasis Area Severity Index (PASI), Body Surface Area and Physician's Global Assessments were collected at baseline and months 3, 6, 12, 18 and 24 during treatment. Adverse events and reasons for secukinumab withdrawal were collected and classified for analyses. A total of 384 patients were enrolled in the study. Median PASI declined rapidly from 14.3 at baseline to 2.7 at month 3, 2.1 at month 12, and remained low (2.8) at month 24. Within the group of patients with PASI ?10 at baseline (n = 278), 58.3%, 60.4% and 56.5% achieved a PASI90 response at months 3, 12 and 24, respectively. As for absolute PASI, 86.5%, 69.5%, 42.7% and 37% achieved PASI <5, <3, <1 and 0, respectively, at month 3. Secukinumab was more effective in biologic-naïve patients and in those with lower Body Mass Index. Secukinumab presented a good long-term safety profile. Secukinumab was effective and safe in a routine clinical setting, in a large cohort of patients with moderate-to-severe plaque psoriasis, in the short-, medium- and long-term (up to 24months).

 Fuente: Dermatologic therapy 2022;e15929

Editorial: Wiley

 Fecha de publicación: 12/10/2022

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/dth.15929

ISSN: 1529-8019,1396-0296

Url de la publicación: https://doi.org/10.1111/dth.15929

Autores/as

CHICHARRO, PABLO

LLAMAS-VELASCO, MAR

HERRERA ACOSTA, ENRIQUE

VIDAL, DAVID

VILARRASA, EVA

RIVERA-DÍAZ, RAQUEL

DE-LA-CUEVA, PABLO

MARTORELL-CALATAYUD, ANTONIO

BALLESCÀ, FERRÁN

BELINCHÓN, ISABEL

CARRETERO, GREGORIO

RODRÍGUEZ, LOURDES

ROMERO-MATÉ, ALBERTO

PUJOL-MONCUSÍ, JOSEP

SALGADO, LAURA

SAHUQUILLO-TORRALBA, ANTONIO

COTO-SEGURA, PABLO

BANIANDRÉS RODRÍGUEZ, OFELIA

FELTES, ROSA