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Acinetobacter baumannii and A. pittii clinical isolates lack adherence and cytotoxicity to lung epithelial cells in vitro

Abstract: The molecular and genetic basis of Acinetobacter baumannii and Acinetobacter pittii virulence remains poorly understood, and there is still lack of knowledge in host cell response to these bacteria. In this study, we have used eleven clinical Acinetobacter strains (A. baumannii n = 5; A. pittii n = 6) to unravel bacterial adherence, invasion and cytotoxicity to human lung epithelial cells. Our results showed that adherence to epithelial cells by Acinetobacter strains is scarce and cellular invasion was not truly detected. In addition, all Acinetobacter strains failed to induce any cytotoxic effect on A549 cells.

 Fuente: Microbes and Infection, 2016, 18(9), 559-564

 Editorial: Elsevier

 Año de publicación: 2016

 Nº de páginas: 4

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.micinf.2016.05.002

 ISSN: 1286-4579,1769-714X

 Url de la publicación: https://doi.org/10.1016/j.micinf.2016.05.002

Autoría

LÁZARO DÍEZ, MARÍA

NAVASCUÉS LEJARZA, TERESA

REMUZGO MARTÍNEZ, SARA

JESUS NAVAS MENDEZ

JOSE MANUEL ICARDO DE LA ESCALERA

ACOSTA, FÉLIX

LUIS MARTINEZ MARTINEZ

RAMOS VIVAS, JOSÉ