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Abstract: The molecular and genetic basis of Acinetobacter baumannii and Acinetobacter pittii virulence remains poorly understood, and there is still lack of knowledge in host cell response to these bacteria. In this study, we have used eleven clinical Acinetobacter strains (A. baumannii n = 5; A. pittii n = 6) to unravel bacterial adherence, invasion and cytotoxicity to human lung epithelial cells. Our results showed that adherence to epithelial cells by Acinetobacter strains is scarce and cellular invasion was not truly detected. In addition, all Acinetobacter strains failed to induce any cytotoxic effect on A549 cells.
Fuente: Microbes and Infection. Volume 18, Issue 9, September 2016, Pages 559-564
Editorial: Elsevier
Año de publicación: 2016
Nº de páginas: 4
Tipo de publicación: Artículo de Revista
DOI: 10.1016/j.micinf.2016.05.002
ISSN: 1286-4579,1769-714X
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LÁZARO DÍEZ, MARÍA
NAVASCUÉS LEJARZA, TERESA
REMUZGO MARTÍNEZ, SARA
JESUS NAVAS MENDEZ
JOSE MANUEL ICARDO DE LA ESCALERA
ACOSTA, FÉLIX
LUIS MARTINEZ MARTINEZ
RAMOS VIVAS, JOSÉ
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