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Abstract: While post-transcriptional control is thought to be required at the periphery of neurons and glia, its extent is unclear. Here, we investigate systematically the spatial distribution and expression of mRNA at single molecule sensitivity and their corresponding proteins of 200 YFP trap lines across the intact Drosophila nervous system. 97.5% of the genes studied showed discordance between the distribution of mRNA and the proteins they encode in at least one region of the nervous system. These data suggest that post-transcriptional regulation is very common, helping to explain the complexity of the nervous system. We also discovered that 68.5% of these genes have transcripts present at the periphery of neurons, with 9.5% at the glial periphery. Peripheral transcripts include many potential new regulators of neurons, glia, and their interactions. Our approach is applicable to most genes and tissues and includes powerful novel data annotation and visualization tools for post transcriptional regulation.
Fuente: Journal of Cell Biology, 2023, 222(6), e202205129
Editorial: Rockefeller University Press
Fecha de publicación: 01/05/2023
Nº de páginas: 26
Tipo de publicación: Artículo de Revista
DOI: 10.1083/jcb.202205129
ISSN: 0021-9525,1540-8140
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TITLOW, JOSHUA S.
KIOURLAPPOU, MARIA
ANA ROSA PALANCA CUÑADO
LEE, JEFFREY Y.
GALA, DALIA S.
ENNIS, DARRAGH
YU, JOYCE J.S.
YOUNG, FLORENCE L.
SUSANO PINTO, DAVID MIGUEL
GARFORTH, SAM
FRANCIS, HELENA S.
STRIVENS, FINN
MULVEY, HUGH
DALLMAN-PORTER, ALEX
THORNTON, STACI
ARMAN, DIANA
MILLARD, MARISSA J.
JARVELIN, AINO I.
THOMPSON, MARY KAY
SARGENT, MARTIN
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