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 Detalle_Publicacion

Lack of association between TLR4 rs4986790 polymorphism and risk of cardiovascular disease in patients with rheumatoid arthritis

Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) mortality. Toll-like receptor-4 (TLR4) activates the innate immune response via NF-kB pathway and mitogen activated protein kinase signaling, leading to expression of proinflammatory cytokines and chemokines. The G allele of TLR4 rs4986790 (+ 896A > G, Asp299Gly) gene polymorphism has been implicated in reduction of risk of atherosclerosis. In this study, 1481 RA patients fulfilling the 1987 American College of Rheumatology (ACR) criteria were genotyped for the rs4986790 TLR4 variant to determine the influence of this variant in the risk of CV events in these patients. Also, HLA-DRB1 status was determined using molecular based methods. Moreover, potential influence of rs4986790 variant in the development of subclinical atherosclerosis was assessed in a subgroup of RA patients with no history of CV events by the measurement of surrogate markers of subclinical atherosclerosis. No statistically significant differences in allele or genotype frequencies for the rs4986790 variant between RA patients who experienced CV events or not were found. Likewise, no significant association be tween this gene variant and any of the surrogate markers of subclinical atherosclerosis was found. In summary, results in our study do not support the hypothesis that the rs4986790 (+ 896A > G, Asp299Gly) TLR4 variant may influence predisposition for subclinical atherosclerosis and clinically evident CV disease in RA patients.

 Autoría: García-Bermúdez M., López-Mejías R., González-Juanatey C., Castañeda S., Miranda-Filloy J.A., Blanco R., Fernández-Gutiérrez B., Balsa A., González-Alvaro I., Gómez-Vaquero C., Llorca J., Martín J., González-Gay M.A.,

 Fuente: DNA and Cell Biology, 2012, 31(7), 1214-1220

Editorial: Mary Ann Liebert

 Año de publicación: 2012

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1089/dna.2011.1582

ISSN: 1044-5498,1557-7430

Url de la publicación: https://doi.org/10.1089/dna.2011.1582

Autoría

GARCÍA-BERMÚDEZ, MERCEDES

RAQUEL LOPEZ MEJIAS

GONZÁLEZ-JUANATEY, CARLOS

CASTAÑEDA, SANTOS

MIRANDA-FILLOY, JOSÉ A.

FERNÁNDEZ-GUTIÉRREZ, BENJAMÍN

BALSA, ALEJANDRO

GONZÁLEZ-ÁLVARO, ISIDORO

GÓMEZ-VAQUERO, CARMEN

FRANCISCO JAVIER LLORCA DIAZ

MARTÍN, JAVIER