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Abstract: Richter transformation (RT) refers to the progression of chronic lymphocytic leukemia, the most prevalent leukemia among adults, into a highly aggressive lymphoproliferative disorder, primarily a diffuse large B-cell lymphoma. This is a severe complication that continues to be a therapeutic challenge and remains an unmet medical need. Over the last five years, significant advances have occurred in uncovering the biological processes leading to the RT, refining criteria for properly diagnose RT from other entities, and exploring new therapeutic options beyond the ineffective chemotherapy. This review summarizes current knowledge in RT, including recent advances in the understanding of the pathogenesis of RT, in the classification of RT, and in the development of novel therapeutic strategies for this grave complication
Fuente: Cancer Treatment Reviews, 023, 120, 102619
Editorial: London Academic Press
Año de publicación: 2023
Nº de páginas: 18
Tipo de publicación: Artículo de Revista
DOI: 10.1016/j.ctrv.2023.102619
ISSN: 1532-1967,0305-7372
Proyecto español: PI17/00943
Url de la publicación: https://doi.org/10.1016/j.ctrv.2023.102619
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ABRISQUETA, PAU
NADEU, FERRAN
BOSCH-SCHIPS, JAN
IACOBONI, GLORIA
SERNA, ANGEL
CABIRTA, ALBA
LUCRECIA YAÑEZ SAN SEGUNDO
QUINTANILLA-MARTINEZ, LETICIA
BOSCH, FRANCESC
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