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Serum alpha-CGRP levels are increased in COVID-19 patients with headache indicating an activation of the trigeminal system

Abstract: Background Headache is among the most frequent symptoms of acute COVID-19 infection. Its mechanisms remain obscure, but due to its migraine-like characteristics, the activation of the trigeminal system could account for its underlying pathophysiology. Methods Our aim was to compare the serum levels of CGRP, as a theoretical marker of trigemino-vascular activation, in 25 COVID-19 inpatients with lung involvement experiencing headache, against 15 COVID-19 inpatients without headache and with those of 25 matched healthy controls with no headache history. Results Morning serum alpha-CGRP levels, as measured by ELISA (Abbexa, UK), were increased in COVID-19 patients with headache (55.2±34.3 pg/mL) vs. controls (33.9±14.0 pg/mL) (p?

 Fuente: BMC Neurology, 2023, 23, 109

Editorial: BioMed Central

 Año de publicación: 2023

Nº de páginas: 4

Tipo de publicación: Artículo de Revista

 DOI: 10.1186/s12883-023-03156-z

ISSN: 1471-2377

Autores/as

GÁRATE, GABRIEL

TORIELLO, MARÍA

GONZÁLEZ-QUINTANILLA, VICENTE

SARA PEREZ PEREDA

MADERA, JORGE

PASCUAL, MARTA