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 Detalle_Publicacion

HLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19

Abstract: We analyzed the association between HLA polymorphisms and susceptibility to SARS-CoV-2 infection and disease severity. Genotyping data from a total of 9373 COVID-19-positive cases from the Spanish Coalition to Unlock Research on Host Genetics on COVID-19 (SCOURGE) consortium and 5943 population controls were included in the study. We found an association of the alleles HLA-B*14:02 and HLA-C*08:02 with a lower risk to COVID-19 infection (p = 0.006, OR = 0.84, 95% CI = [0.75-0.95], p = 0.024, OR = 0.86, 95% CI = [0.78-0.95], respectively). We also found the alleles HLA-A*11:01 and HLA-C*04:01 associated with disease severity (p = 0.033, OR = 1.16, 95% CI = [1.04-1.31], p = 0.045, OR = 1.14, 95% CI = [1.05-1.25], respectively). These results suggest that an effective presentation of viral peptides by HLA class I alleles involve a faster infection clearance, decreasing the susceptibility and severity of COVID-19.

 Autoría: Castro-Santos P., Rojas-Martinez A., Riancho J.A., Lapunzina P., Flores C., Carracedo A., Díaz-Peña R., Abellan J., Acosta-Isaac R., Aguado J.M., Aguilar C., Aguilera-Albesa S., Sabbagh A.A., Alba J., Albu S., Alcalá-Gallardo K.A.M., Alcoba-Florez J., Batres S.A., Algarin-Lara H.R., Almadana V., Almeida J., Almoguera B., Alonso M.R., Alvarez N., Álvarez-Benítez Y., Álvarez-Navia F., Walther R.A.S., Andreu-Bernabeu Á., Antonijoan M.R., Ara

 Fuente: HLA, 2023,1-9

Editorial: Wiley Blackwell

 Año de publicación: 2023

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/tan.15160

ISSN: 2059-2302,2059-2310

Url de la publicación: https://doi.org/10.1111/tan.15160

Autores/as

CASTRO-SANTOS, PATRICIA

ROJAS-MARTÍNEZ, AUGUSTO

LAPUNZINA, PABLO

FLORES, CARLOS

CARRACEDO, ÁNGEL

DÍAZ-PEÑA, ROBERTO