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 Detalle_Publicacion

In vivo transmission of a plasmid coharbouring blaDHA-1 and qnrB genes between Escherichia coli and Serratia marcescens

Abstract: We report a Serratia marcescens and an Escherichia coli isolate simultaneously detected in the same patient. Both isolates showed susceptibility patterns suggestive of harbouring a plasmid-mediated AmpC b-lactamase (pACBL) and a plasmid-encoded quinolone resistance (PMQR). PCR-based replicon, MOB typing, plasmid profile and Southern hybridization analyses revealed that both isolates coharboured blaDHA-1 and qnrB genes on the same IncL/M-MOBP13 plasmid approximately 70 kb in size. Together with the fact that both plasmids were conjugative in the laboratory, these results strongly suggest that a horizontal transfer event could take place in vivo. This is the first report of an isolate of S. marcescens harbouring a pACBL. The only phenotypic method that suggests the presence of a pACBL in an isolate harbouring an inducible chromosomal AmpC enzyme is the observation of scattered colonies near the edge of the inhibition zones of some b-lactams. The presence of both resistance genes on the same plasmid and the reported increase in PMQR could perhaps explain the widespread distribution of blaDHA-1 genes.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Mata C., Miró E., Mirelis B., Garcillán-Barcia M., De La Cruz F., Coll P., Navarro F.,

 Fuente: FEMS Microbiology Letters, 2010, 308(1), 24-28

Editorial: Oxford University Press

 Año de publicación: 2010

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/j.1574-6968.2010.01980.x

ISSN: 0378-1097,1574-6968

 Proyecto español: BFU2008-00995/BMC

Url de la publicación: https://doi.org/10.1111/j.1574-6968.2010.01980.x

Autoría

MATA, CATERINA

MIRÓ, ELISENDA

MIRELIS, BEATRIZ

NAVARR, FERRÁN