Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

White matter integrity and cognitive impairment in first-episode psychosis

Abstract: Objective: Impaired cognitive function has been identified as a core feature of schizophrenia. However, a significant proportion of patients do not show any cognitive deficits. The aim of this study was to assess if there were differences in white matter integrity between patients with and without cognitive impairment. Method: A diffusion tensor imaging study and neurocognitive assessment were conducted in 49 patients with firstepisode psychosis and 41 healthy comparison subjects. Subjects were assessed using the Continuous Performance Test, the Grooved Pegboard Test, the Rey Auditory Verbal Learning Test, and the Trail Making Test Part B. For each test, the patient sample was subdivided according to performance, with those scoring more than one standard deviation below the normative mean categorized as impaired. For each cognitive domain, white matter fractional anisotropy in deficit and nondeficit subgroups was compared using a voxel-based analysis. A nonparametric statistical method, controlling for multiple comparisons, was applied. Results: Impairment on the Trail Making Test Part B was associated with reduced fractional anisotropy in the right/left anterior thalamic radiation and inferior frontooccipital fasciculus, forceps minor, and left superior and inferior longitudinal fasciculi. Patients exhibiting Grooved Pegboard Test impairment showed reduced fractional anisotropy in the forceps minor, inferior fronto-occipital fasciculus, anterior thalamic radiation, and corticospinal and corticopontine tracts. Impaired performance on the Rey Auditory Verbal Learning Test and Continuous Performance Test was not associated with significant differences in fractional anisotropy. Conclusions: Deficits in executive and motor functioning in patients with firstepisode psychosis are associated with reductions in white matter integrity in the major fasciculi that connect the frontal and temporal cortices as well as in pathways connecting cortical and subcortical regions. Their presence at the onset of illness, in minimally medicated patients, indicates that these findings are not attributable to effects of chronic illness or its treatment

 Fuente: The American journal of psychiatry, 2010, 167(4), 451-458

Editorial: American Psychiatric Association

 Fecha de publicación: 01/04/2010

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1176/appi.ajp.2009.09050716

ISSN: 0002-953X,1535-7228

Url de la publicación: https://doi.org/10.1176/appi.ajp.2009.09050716

Autoría

ROCIO PEREZ IGLESIAS

DIANA TORDESILLAS GUTIERREZ

MCGUIRE, PHILIP K.

BARKER, GARETH J.

ROBERTO ROIZ SANTIAÑEZ

IGNACIO MATA PASTOR

JOSÉ MANUEL RODRÍGUEZ SÁNCHEZ

MARIA ROSA AYESA ARRIOLA

JOSE LUIS VAZQUEZ BARQUERO

BENEDICTO CRESPO FACORRO