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Common allelic variants of the farnesyl diphosphate synthase gene influence the response of osteoporotic women to bisphosphonates

Abstract: Farnesyl diphosphate synthase (FDPS) is necessary for osteoclast survival and activity and is considered as a major molecular target of aminobisphosphonates. Our objective was to analyze the influence of FDPS polymorphisms on bone mineral density (BMD) and the response to antiresortive drugs. Three single-nucleotide polymorphisms of FDPS were analyzed in 1186 postmenopausal women. There was only a marginally significant association of baseline hip BMD with rs11264359 alleles (P=0.043). However, among 191 women receiving antiresortive therapy, there was a very significant association between rs2297480 or rs11264359 alleles and the BMD changes after aminobisphosphonate therapy for an average period of 2.5 years (P=0.001). The genotype explained 7.2% of the variance in the BMD response. On the other hand, there was no association between the BMD changes after raloxifene therapy and any of the polymorphisms studied. These results suggest that common polymorphisms of the FDPS gene influence the response to aminobisphosphonates.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Olmos J.M., Zarrabeitia M.T., Hernández J.L., Sãudo C., González-Macías J., Riancho J.A.,

 Fuente: Pharmacogenomics Journal, 2012, 12(3), 227-232

Editorial: Springer Nature

 Fecha de publicación: 01/06/2012

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/tpj.2010.88

ISSN: 1470-269X,1473-1150

Url de la publicación: https://doi.org/10.1038/tpj.2010.88