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Kinetic and parametric analysis of the separation of ultra-small, aqueous superparamagnetic iron oxide nanoparticle suspensions under quadrupole magnetic fields

Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) have gathered tremendous scientific interest, especially in the biomedical field, for multiple applications, including bioseparation, drug delivery, etc. Nevertheless, their manipulation and separation with magnetic fields are challenging due to their small size. We recently reported the coupling of cooperative magnetophoresis and sedimentation using quadrupole magnets as a promising strategy to successfully promote SPION recovery from media. However, previous studies involved SPIONs dispersed in organic solvents (non-biocompatible) at high concentrations, which is detrimental to the process economy. In this work, we investigate, for the first time, the magnetic separation of 20 nm and 30 nm SPIONs dispersed in an aqueous medium at relatively low concentrations (as low as 0.5 g·L-1) using our custom, permanent magnet-based quadrupole magnetic sorter (QMS). By monitoring the SPION concentrations along the vessel within the QMS, we estimated the influence of several variables in the separation and analyzed the kinetics of the process. The results obtained can be used to shed light on the dynamics and interplay of variables that govern the fast separation of SPIONs using inexpensive permanent magnets.

 Autoría: Ciannella S., Wu X., González-Fernández C., Rezaei B., Strayer J., Choe H., Wu K., Chalmers J., Gomez-Pastora J.,

 Fuente: Micromachines, 2023, 14(11), 2107

 Editorial: MDPI

 Fecha de publicación: 17/11/2023

 Nº de páginas: 17

 Tipo de publicación: Artículo de Revista

 DOI: 10.3390/mi14112107

 ISSN: 2072-666X

Autoría

CIANNELLA, STEFANO

WU, XIAN

REZAEI , BAHAREH

STRAYER , JACOB

CHOE , HYEON

WU , KAI

JEFREY J. CHALMERS

GOMEZ PASTORA , JENIFER