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Outcomes for patients with EBV-positive PTLD post-allogeneic HCT after failure of rituximab-containing therapy

Abstract: Epstein-Barr virus-positive (EBV+) post-transplant lymphoproliferative disease (PTLD) is an ultra-rare and aggressive condition that may occur following allogeneic hematopoietic cell transplant (HCT) due to immunosuppression. Approximately half of EBV+ PTLD cases are relapsed or refractory (R/R) to initial rituximab-containing therapy. There are limited treatment options and no standard of care for patients with R/R EBV+ PTLD, and little is known about their treatment history and outcomes. We performed a multinational, multicenter, retrospective chart review of patients with R/R EBV+ PTLD following HCT to describe patients' demographic and disease characteristics, treatment history, and overall survival (OS) from rituximab failure. Among 81 patients who received initial treatment with rituximab as monotherapy (84.0%) or in combination with chemotherapy (16.0%), median time from HCT to PTLD diagnosis was 3.0 months and median OS was 0.7 months. Thirty-six patients received a subsequent line of treatment. The most frequent causes of death were PTLD (56.8%), graft-versus-host disease (13.5%) and treatment-related mortality (10.8%). In multivariate analysis, early PTLD onset and lack of response to initial treatment were associated with mortality. This real-world study demonstrates that the prognosis of patients with R/R EBV+ PTLD following HCT remains poor, highlighting the urgent unmet medical need in this population.

 Fuente: Bone Marrow Transplantation, 2023

 Editorial: Nature Publishing Group

 Año de publicación: 2023

 Nº de páginas: 7

 Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s41409-023-02127-9

 ISSN: 0268-3369,1476-5365

 Url de la publicación: https://doi.org/10.1038/s41409-023-02127-9

Autoría

SOCIÉ, GÉRARD

BARBA, PERE

BARLEV, ARIE

SANZ, JAIME

GARCÍA-CADENAS, IRENE

CHEVALLIER, PATRICE

FAGIOLI, FRANCA

GUZMÁN-BECERRA, NORMA

KUMAR , DEEPALI

LJUNGMAN, PER

PIGNEUX, ARNAUD

SADETSKY, NATALIA

SHADMAN, MAZYAR

STOREK, JAN

THIRUMALAI, DHANALAKSHMI

XING, BAODONG

MOTHY, MOHAMED