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Association of occupational heat exposure and colorectal cancer in the MCC-Spain study

Abstract: Objective: Heat exposure and heat stress/strain is a concern for many workers. There is increasing interest in potential chronic health effects of occupational heat exposure, including cancer risk. We examined potential associations of occupational heat exposure and colorectal cancer (CRC) risk in a large Spanish multi-case--control study. Methods: We analyzed data on 1198 histologically confirmed CRC cases and 2690 frequency-matched controls. The Spanish job-exposure matrix, MatEmEsp, was used to assign heat exposure estimates to the lifetime occupations of participants. Three exposure indices were assessed: ever versus never exposed, cumulative exposure and duration (years). We estimated odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression adjusting for potential confounders. Results: Overall, there was no association of ever, compared with never, occupational heat exposure and CRC (OR 1.09, 95% CI 0.92-1.29). There were also no associations observed according to categories of cumulative exposure or duration, and there was no evidence for a trend. There was no clear association of ever occupational heat exposure and CRC in analysis conducted among either men or women when analyzed separately. Positive associations were observed among women in the highest categories of cumulative exposure (OR 1.81, 95% CI 1.09-3.03) and duration (OR 2.89, 95% CI 1.50-5.59) as well as some evidence for a trend (P<0.05). Conclusion: Overall, this study provides no clear evidence for an association between occupational heat exposure and CRC.

 Fuente: Scandinavian Journal of Work, Environment & Health, 2023, 49(3), 211-221

 Editorial: Nordic Association of Occupational Safety and Health NOROSH.

 Año de publicación: 2023

 Nº de páginas: 11

 Tipo de publicación: Artículo de Revista

 ISSN: 0355-3140,1795-990X

 Proyecto español: CEX2018-000806-S

 Url de la publicación: https://doi.org/10.5271/sjweh.4082

Autoría

HINCHLIFFE, ALICE

KOGEVINAS, MANOLIS

MOLINA, ANTONIO J.

MORENO, VÍCTOR

ARAGONÉS, NURIA

CASTAÑO-VINYALS, GEMMA

JOSE JUAN JIMENEZ MOLEON

EDERRA, MARÍA

AMIANO, PILAR

MOLINA-BARCELÓ, ANA

GUILLERMO FERNANDEZ TARDON

ALGUACIL, JUAN

CHIRLAQUE, MARÍA-DOLORES

HERNÁNDEZ-SEGURA, NATALIA

PÉREZ-GÓMEZ, BEATRIZ

POLLÁN, MARINA

TURNER, MICHELLE C.