Abstract: Aim: To explore if the entire duration of active psychosis (DAP) is related to neurocognitive performance at baseline and at 3-year follow-up in patients with first episode psychosis (FEP). Methods: DAP was estimated for 481 FEP patients. A neuropsychological battery was administered to measure neurocognitive specific domains, and a global indicator of neurocognitive impairment (global deficits score, GDS) was calculated. According to the DAP quartiles, four subgroups were formed, and these were compared. In addition, a logistic regression analysis was carried out to predict neurocognitive impairment at 3-year follow-up. Results: FEP patients with the longest DAP (more than 18.36?months) presented a more severe global neurocognitive impairment evidenced in their GDS, both at baseline (F = 5.53; p? .01) and at 3-year follow-up (F = 4.16; p? .01). Moreover, a subgroup of participants with DAP between 7.40 and 18.36?months showed a specific attentional decline over the 3-year follow-up (F = 3.089; p? .05).The logistic regression model showed that sex (Wald = 7.29, p?

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