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Abstract: Although new therapies have doubled the survival of multiple myeloma patients, this remains an incurable disease. It has been postulated that the so-called myeloma cancer stem cells would be responsible for tumor initiation and relapse but their unequivocal identification remains unclear. Here, we investigated in a panel of myeloma cell lines the presence of CD20+ cells harboring a stem-cell phenotype. Thus, only a small population of CD20dim+ cells (0.3%) in the RPMI-8226 cell line was found. CD20dim+ RPMI-8226 cells expressed the plasma cell markers CD38 and CD138 and were CD19?CD27?. Additionally, CD20dim+ RPMI-8226 cells did not exhibit stem-cell markers as shown by gene expression profiling and the aldehyde dehydrogenase assay. Furthermore, we demonstrated that CD20dim+ RPMI-8226 cells are not essential for CB17-SCID mice engraftment and show lower self-renewal potential than the CD20? RPMI-8226 cells. These results do not support CD20 expression for the identification of myeloma cancer stem cells.
Fuente: Haematologica, 2012, 97(7), 1110-1114
Editorial: Ferrata Storti Foundation
Año de publicación: 2012
Nº de páginas: 5
Tipo de publicación: Artículo de Revista
DOI: 10.3324/haematol.2011.057372
ISSN: 0390-6078,1592-8721
Url de la publicación: https://doi.org/10.3324/haematol.2011.057372
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PAÍNO, TERESA
ENRIQUE MARIA OCIO SAN MIGUEL
PAIVA, BRUNO
SAN-SEGUNDO, LAURA
GARAYOA, MERCEDES
GUTIÉRREZ, NORMA C.
EUGENIA SARASQUETE M.
PANDIELLA, ATANASIO
ORFAO, ALBERTO
SAN MIGUEL, JESÚS F.
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