Estamos realizando la búsqueda. Por favor, espere...
1583
37
170
29013
4402
2599
347
386
Abstract: Evidence suggests that the basal forebrain (BF) cholinergic system degenerates early in the course of Alzheimer's disease (AD), likely due to the vulnerability of BF cholinergic neurons to tau pathology. However, it remains unclear whether the presence of tauopathy is the only requirement for initiating the BF degeneration in asymptomatic subjects at risk for AD (AR-AD), and how BF structural deficits evolve from normal aging to preclinical and prodromal AD. Here, we provide human in vivo magnetic resonance imaging evidence supporting that abnormal cerebrospinal fluid levels of phosphorylated tau (T+) are selectively associated with bilateral volume loss of the nucleus basalis of Meynert (nbM, Ch4) in AR-AD individuals. Spreading of atrophy to medial septum and vertical limb of diagonal band Broca (Ch1-Ch2) occurred in both preclinical and prodromal AD. With the exception of A+, all groups revealed significant correlations between volume reduction of BF cholinergic compartments and atrophy of their innervated regions. Overall, these results support the central role played by tauopathy in instigating the nbM degeneration in AR-AD individuals and the necessary coexistence of both AD proteinopathies for spreading damage to larger BF territories, thus affecting the core of the BF cholinergic projection system
Fuente: Cerebral Cortex, 2020, 30(4), 2083-2098
Editorial: Oxford University Press
Año de publicación: 2020
Nº de páginas: 16
Tipo de publicación: Artículo de Revista
DOI: 10.1093/cercor/bhz224
ISSN: 1047-3211,1460-2199
Leer publicación
CANTERO, JOSE L.
ATIENZA, MERCEDES
LAGE, CARMEN
ZABORSZKY, LASZLO
VILAPLANA, EDUARD
LÓPEZ-GARCÍA, SARA
POZUETA, ANA
ELOY MANUEL RODRIGUEZ RODRIGUEZ
BLESA, RAFAEL
ALCOLEA, DANIEL
LLEO, ALBERTO
SÁNCHEZ-JUAN, PASCUAL
FORTEA, JUAN
Volver