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Abstract: Several studies have analyzed the potential of T regulatory cells (Treg cells) as biomarkers of acute rejection (AR). The aim of the present multicenter study was to correlate the percentage of peripheral Treg cells in liver graft recipients drawn at baseline up to 12 months after transplantation with the presence of AR. The percentage of central memory (cm) Treg cells (CD4+CD25highCD45RO+CD62L+) was monitored at pre-transplant and at 1 and 2 weeks, and 1, 2, 3 and 6 months and 1 year posttransplantation. The same validation standard operating procedures were used in all participating centers. Fifteen patients developed AR (23.4%). Hepatitis C virus recurrence was observed in 16 recipients, who displayed low peripheral blood cmTreg levels compared with patients who did not. A steady increase of cmTregs was observed during the first month after transplantation with statistically significant differences between AR and non-AR patients. The high frequency of memory Treg cells allowed us to monitor rejection episodes during the first month post-transplantation. On the basis of these data, we developed a prediction model for assessing risk of AR that can provide clinicians with useful information for managing patients individually and customizing immunosuppressive therapies.
Fuente: Int Immunol. 2016 Feb;28(2):55-64
Editorial: Oxford : [Oxford University Press]
Fecha de publicación: 01/02/2016
Nº de páginas: 10
Tipo de publicación: Artículo de Revista
DOI: 10.1093/intimm/dxv048
ISSN: 0953-8178,1460-2377
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BOIX GINER, FRANCISCO
MILLÁN, OLGA
DAVID SAN SEGUNDO ARRIBAS
PEDRO MUÑOZ CACHO
MANCEBO, ESTHER
LLORENTE, SANTIAGO
RAFAEL VALDIVIA, LOURDES
RIMOLA, ANTONI
EMILIO FABREGA GARCIA
MROWIEC, ANNA
ALLENDE, LUIS
MINGUELA, ALFREDO
BOLARÍN, JOSÉ M.
PAZ ARTAL, ESTELA
MARCOS LOPEZ HOYOS
BRUNET, MERCÉ
MURO, MANUEL
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