Abstract: Systemic autoimmune diseases (SADs) are associated with lower bone mass and an increased risk of fractures. Sclerostin has a pivotal role in bone metabolism. Available data on circulating sclerostin levels in healthy subjects are limited, whereas those in SAD patients are absent. Our objective was to determine circulating sclerostin concentrations in systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and Crohn?s disease (CD) patients, and to analyze the factors associated with sclerostin concentrations. In this cross-sectional case?control study, serum sclerostin levels were measured in 38 SLE patients, 20 CD patients, 8 SSc patients and 20 healthy controls using a sclerostin ELISA. The mean values of the sclerostin (95% confidence interval) were 35.36 pmol l1 (12?101) in patients and 33.92 pmol l1 (2.31?100) in control subjects. The mean sclerostin value was 36.4 pmol l1 (22.1?48.5) in SLE patients, 26.7 pmol l1 (17.3?36.3) in CD patients and 51.8 pmol l1 (26.5?77.1) in SSc patients (P¼0.001). Serum sclerostin levels were positively correlated with age (Po0.001), body mass index (BMI) (P¼0.01) and lumbar spine Z-score (P¼0.001) and
negatively with creatinine clearance (P¼0.001). Glucocorticoid treatment did not affect sclerostin levels. Sclerostin
levels seem to have a heterogeneous pattern in different autoimmune diseases. SLE and SSc patients did not differ from
healthy controls regarding sclerostin levels. The CD group had significantly lower values compared with SSc patients.
Factors associated with sclerostin levels in autoimmune diseases seem to be the same than in the general population.
Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria
Fuente: BoneKEy Reports, 2016, 5, 775
Editorial: Nature Publishing Group on behalf of the International Bone & Mineral Society
Año de publicación: 2016
Nº de páginas: 4
Tipo de publicación: Artículo de Revista
DOI: 10.1038/bonekey.2016.2
ISSN: 2047-6396