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Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease

Abstract: The diagnostic value of cerebrospinal fluid (CSF) biomarkers is well established in Alzheimer's disease, but our current knowledge about how abnormal CSF levels affect cerebral integrity, at local and network levels, is incomplete in asymptomatic older adults. Here, we have collected CSF samples and performed structural magnetic resonance imaging scans in cognitively normal elderly as part of a cross-sectional multicenter study (SIGNAL project). To identify group differences in cortical thickness, white matter volume, and properties of structural networks, participants were split into controls (N = 20), positive amyloid-? (A?1?42 +) (N = 19), and positive phosphorylated tau (N = 18). The A?1?42 + group exhibited thickening of middle temporal regions, while positive phosphorylated tau individuals showed thinning in the superior parietal and orbitofrontal cortices. Subjects with abnormal CSF biomarkers further showed regional white matter atrophy and more segregated cortical networks, the A?1?42 + group showing heightened isolation of cingulate and temporal cortices. Collectively, these findings highlight the relevance of combining structural brain imaging and connectomics for in vivo tracking of Alzheimer's disease lesions in asymptomatic stages.

 Fuente: Neurobiology of Aging Volume 64, April 2018, Pages 58-67

Editorial: Elsevier

 Fecha de publicación: 01/04/2018

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.neurobiolaging.2017.12.010

ISSN: 0197-4580,1558-1497

Autoría

CANTERO, JOSÉ L.

ATIENZA, MERCEDES

PASCUAL SANCHEZ JUAN

JOSE LUIS VAZQUEZ HIGUERA

ANA POZUETA CANTUDO

ANDREA GONZALEZ SUAREZ

VILAPLANA, EDUARD

PEGUEROLES, JORDI

MONTAL, VÍCTOR

BLESA, RAFAEL

ALCOLEA, DANIEL

LLEO, ALBERTO

FORTEA, JUAN