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 Detalle_Publicacion

Markers of endothelial damage in patients with chronic kidney disease on hemodialysis

Abstract: Patients with Stage 5 chronic kidney disease who are on hemodialysis (HD) remain in a chronic inflammatory state, characterized by the accumulation of uremic toxins that induce endothelial damage and cardiovascular disease (CVD). Our aim was to examine microvesicles (MVs), monocyte subpopulations, and angiopoietins (Ang) to identify prognostic markers in HD patients with or without diabetes mellitus (DM). A total of 160 prevalent HD patients from 10 centers across Spain were obtained from the Biobank of the Nephrology Renal Network (Madrid, Spain): 80 patients with DM and 80 patients without DM who were matched for clinical and demographic criteria. MVs from plasma and several monocyte subpopulations (CD142/CD16, CD14/ CD162) were analyzed by flow cytometry, and the plasma concentrations of Ang1 and Ang2 were quantified by ELISA. Data on CVD were gathered over the 5.5 yr after these samples were obtained. MV level, monocyte subpopulations (CD14/CD162 and CD142/ CD16), and Ang2-to-Ang1 ratios increased in HD patients with DM compared with non-DM patients. Moreover, MV level above the median (264 MVs/l) was associated independently with greater mortality. MVs, monocyte subpopulations, and Ang2-to-Ang1 ratio can be used as predictors for CVD. In addition, MV level has a potential predictive value in the prevention of CVD in HD patients. These parameters undergo more extensive changes in patients with DM

 Fuente: American Journal of Physiology. Renal Physiology,2017, 312, F673-F681

Editorial: American Physiological Society

 Año de publicación: 2017

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1152/ajprenal.00013.2016

ISSN: 1931-857X,1522-1466

Autores/as

CARMONA, ANDRÉS

AGÜERA, MARIA L.

LUNA RUIZ, CARLOS

BUENDÍA, PAULA

CALLEROS, LAURA

GARCÍA JEREZ, ANDREA

RODRÍGUEZ PUYOL, MANUEL

ARIAS GUILLEN, MARTA

ARRIBA, GABRIEL DE

BALLARIN, JOSE

BERNIS, CARMEN

FERNÁNDEZ, ELVIRA

GARCÍA REBOLLO, SAGRARIO

MANCHA, JAVIER

PESO, GLORIA DEL

PÉREZ, ESTEFANÍA

POCH, ESTEBAN

PORTOLÉS, JOSE M.

RODRÍGUEZ PUYOL, DIEGO