Estamos realizando la búsqueda. Por favor, espere...
1579
37
170
28929
4401
2598
347
381
Abstract: Objective: To assess the effects of non-invasive ventilation (NIV) in emergency department (ED) patients with acute heart failure (AHF) on short term outcomes. Methods: Patients from the EAHFE Registry (a multicenter, observational, multipurpose, cohort-designed database including consecutive AHF patients in 41 Spanish EDs) were grouped based on NIV treatment (NIV+ and NIV?groups). Using propensity score (PS) methodology, we identified two subgroups of patients matched by 38 covariates and compared regarding 30-day survival (primary outcome). Interaction was investigated for age, sex, ischemic cardiomyopathy, chronic obstructive pulmonary disease, AHF precipitated by an acute coronary syndrome (ACS), AHF classified as hypertensive or acute pulmonary edema (APE), and systolic blood pressure (SBP). Secondary outcomes were intensive care unit (ICU) admission; mechanical ventilation; in-hospital, 3-day and 7-day mortality; and prolonged hospitalization (> 7 days). Results: Of 11,152 patients from the EAHFE (age (SD): 80 (10) years; 55.5% women), 718 (6.4%) were NIV+ and had a higher 30-day mortality (HR=2.229; 95%CI=1.861?2.670) (p < 0.001). PS matching provided 2 groups of 490 patients each with no significant differences in 30-day mortality (HR=1.239; 95%CI=0.905?1.696) (p=0.182). Interaction analysis suggested a worse effect of NIV on elderly patients (> 85 years, p < 0.001), AHF associated with ACS (p=0.045), and SBP < 100 mmHg (p < 0.001). No significant differences were found in the secondary endpoints except for more prolonged hospitalizations in NIV+ patients (OR=1.445; 95%CI=1.122?1.862) (p=0.004).Conclusion: The use of NIV to treat AHF in ED is not associated with improved mortality outcomes and should be cautious in old patients and those with ACS and hypotension.
Fuente: European Journal of Internal Medicine Volume 53, July 2018, Pages 45-51
Editorial: Elsevier
Año de publicación: 2018
Nº de páginas: 7
Tipo de publicación: Artículo de Revista
DOI: 10.1016/j.ejim.2018.03.008
ISSN: 0953-6205,1879-0828
Url de la publicación: https://doi.org/10.1016/j.ejim.2018.03.008
Leer publicación
MIRÓ, ÒSCAR
MARTÍNEZ, GEMMA
MASIP, JOSEP
GIL, VÍCTOR
MARTÍN-SÁNCHEZ, FRANCISCO JAVIER
LLORENS, PERE
HERRERO-PUENTE, PABLO
SÁNCHEZ, CAROLINA
RICHARD, FERNANDO
LUCAS-INVERNÓN, JAVIER
GARRIDO, JOSÉ MANUEL
MEBAZAA, ALEXANDRE
RÍOS, JOSÉ
PEACOCK, W. FRANK
HOLLANDER, JUDD E.
JACOB, JAVIER
ICA-SEMES RESEARCH GROUP RESEARCHERS
FUENTES, MARTA
GIL, CRISTINA
HECTOR ALONSO VALLE
Volver