Abstract: Patients with rheumatoid arthritis (RA) have a higher incidence of subclinical atherosclerosis and cardiovascular (CV) disease. It is postulated that the appearance of accelerated atherosclerosis in these patients is a consequence of the inflammation present in the disease. In this study, we aim to determine if baseline disease activity in patients with RA predicts the future development of carotid plaque. A set of consecutive RA patients without a history of CV events, cancer or chronic kidney disease, who did not show carotid plaque in a carotid ultrasound assessment, were prospectively followed up for at least 5 years. At the time of recruitment, CV risk factors and disease-related data, including disease activity scores, were assessed. At the end of the follow-up, a carotid ultrasound was repeated and patients were divided into two groups; those who developed carotid plaque, and those who did not. A multivariable regression analysis was performed to define the predictors for the development of carotid plaque. One hundred and sixty patients with RA were followed up for an average of 6 ± 1 years. After this time, 66 (41%) of the patients had developed carotid plaque, and 94 (59%) did not. Patients with carotid plaque were significantly older (47 ± 13 vs. 55 ± 9 years, p < 0.001) at baseline, were more frequently diabetic (0% vs. 6%, p = 0.028), and had higher total cholesterol (197 ± 36 vs. 214 ± 40 mg/dL, p = 0.004) and LDL cholesterol (114 ± 35 vs. 126 ± 35 mg/dL, p = 0.037) at the beginning of the study. After multivariable adjustment, patients who were in the moderate and high disease activity (DAS28-CRP) categories displayed a higher odds ratio for the appearance of carotid plaque (OR 2.26 [95% CI 1.02?5.00], p = 0.044) compared to those in the DAS-28-CRP remission category. Remarkably, when patients were divided in patients within the low-risk SCORE category, and patients included in the remaining SCORE categories (moderate, high and very high), the relation between DAS28-CRP and the development of carotid plaque was only significant in the low-risk SCORE category. In conclusion, disease activity predicts the future development of subclinical atherosclerosis in patients with RA.
Other publications of the same journal or congress with authors from the University of Cantabria
-
A role for gut microbiome fermentative pathways in fatty liver disease progression - Article
-
Melflufen: A Peptide-Drug Conjugate for the Treatment of Multiple Myeloma - Article
-
Clinical Spectrum of Schistosomiasis: An Update - Article
-
Relationship between depressive symptoms, personality, and binge drinking among university students in Spain - Article
-
Is Routine Prophylaxis Against Pneumocystis jirovecii Needed in Liver Transplantation? A Retrospective Single-Centre Experience and Current Prophylaxis Strategies in Spain - Article
-
Propionate fermentative genes of the gut microbiome decrease in inflammatory bowel disease - Article
-
Body mass index and disease activity in chronic inflammatory rheumatic diseases: results of the cardiovascular in rheumatology (CARMA) project - Article
-
QRISK3 performance in the assessment of cardiovascular risk in patients with inflammatory bowel disease - Article
-
Imaging Tests in the Early Diagnosis of Giant Cell Arteritis - Article
-
Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease - Article
-
Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk - Article
-
Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association - Article
-
Clinical Factors Associated with Reinfection versus Relapse in Infective Endocarditis: Prospective Cohort Study - Article
-
Prevention, Diagnosis and Management of Post-Surgical Mediastinitis in Adults Consensus Guidelines of the Spanish Society of Cardiovascular Infections (SEICAV), the Spanish Society of Thoracic and Cardiovascular Surgery (SECTCV) and the Biomedical Researc - Article
-
Urine Phenylacetylglutamine Determination in Patients with Hyperphenylalaninemia - Article
-
Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome - Article
-
Evolution of mitochondrially derived peptides humanin and MOTSc, and changes in insulin sensitivity during early gestation in women with and without gestational diabetes - Article
-
Sensitization-associated post-COVID-19 symptoms at 6 months are not associated with serological biomarkers at hospital admission in COVID-19 survivors: a secondary analysis of a cohort study - Article
-
Management of Cardiovascular Disease Risk in Rheumatoid Arthritis - Article
-
New insights into renal failure in a cohort of 317 patients with autosomal dominant forms of alport syndrome: report of two novel heterozygous mutations in COL4A3 - Article
-
Multivalvular endocarditis: a rare condition with poor prognosis - Article
-
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU - Article
-
Comorbidity and prognosis in octogenarians with infective endocarditis - Article
-
Hypotension Prediction Index Software to Prevent Intraoperative Hypotension during Major Non-Cardiac Surgery: Protocol for a European Multicenter Prospective Observational Registry (EU-HYPROTECT) - Article
-
IgA Vasculitis: Influence of CD40, BLK and BANK1 Gene Polymorphisms - Article
-
Cirrhosis, a Global and Challenging Disease - Article
-
Portal Vein Thrombosis in the Setting of Cirrhosis: A Comprehensive Review - Article
-
Traumatic brain injury and acute kidney injury-outcomes and associated risk factors - Article
-
Infective endocarditis in diabetic patients: a different profile with prognostic consequences - Article
-
Advances in the treatment of giant cell arteritis - Article
-
Measuring recovery and understanding long-term deficits in balance, ankle mobility and hip strength in people after an open reduction and internal fixation of bimalleolar fracture and their impact on functionality: a 12-month longitudinal study - Article
-
Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the spanish registry - Article
-
Audiovestibular manifestations in patients with primary Raynaud's phenomenon and Raynaud's phenomenon secondary to systemic sclerosis - Article
-
HDL cholesterol efflux and the complement system are linked in systemic lupus erythematosus - Article
-
Red cell distribution width association with subclinical cardiovascular disease in patients with rheumatoid arthritis - Article
-
18F-fluorodeoxyglucose positron emission tomography-computed tomography findings of polymyalgia rheumatica in patients with giant cell arteritis - Article
-
Hematological composite scores in patients with inflammatory bowel disease - Article
-
Risk of recurrence of hepatocarcinoma after liver transplantation: performance of recurrence predictive models in a cohort of transplant patients - Article
-
Positron emission computed tomography spectrum of large vessel vasculitis in a tertiary center: differences in 18F-fluorodeoxyglucose uptake between large vessel vasculitis with predominant cranial and extracranial giant cell arteritis phenotypes - Article
-
Understanding the influence of personality traits on risk of suicidal behaviour in schizophrenia spectrum disorders: a systematic review - Article
-
Malondialdehyde serum levels in a full characterized series of 430 rheumatoid arthritis patients - Article
-
Sexual Satisfaction and Mental Health in Prison Inmates - Article
-
Mental Health and Proximal Stressors in Transgender Men and Women - Article
-
Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time
Course - Article
-
The Spectrum of Interstitial Lung Disease Associated With Autoimmune Diseases: Data of a 3.6-Year Prospective Study From a Referral Center of Interstitial Lung Disease and Lung Transplantation - Article
-
The Different Microbial Etiology of Prosthetic Joint Infections According to Route of Acquisition and Time After Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms - Article
-
Changes in Circulating Lysyl Oxidase-Like-2 (LOXL2) Levels, HOMA, and Fibrosis after Sustained Virological Response by Direct Antiviral Therapy - Article
-
Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis - Article
-
Association of Human Leukocyte Antigens Class II Variants with Susceptibility to Hidradenitis Suppurativa in a Caucasian Spanish Population - Article
-
The performance of vascular age in the assessment of cardiovascular risk of patients with rheumatoid arthritis - Article
-
Anti-IL-6 Receptor Tocilizumab in Refractory Graves´ Orbitopathy: National Multicenter Observational Study of 48 Patients - Article
-
Biologic Therapy in Refractory Non-Multiple Sclerosis Optic Neuritis Isolated or Associated to Immune Mediated Inflammatory Diseases. A Multicenter Study - Article
-
Rituximab in the treatment of interstitial lung disease associated with autoimmune diseases: experience from a single referral center and literature review - Article