Searching. Please wait…
1580
37
171
29348
4420
2606
347
392
Abstract: (1) Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study evaluated the diagnostic performance of different LTBI screening strategies in patients with inflammatory bowel disease (IBD). (2) Methods: Patients in the Spanish ENEIDA registry with IBD screened for LTBI between January 2003 and January 2018 were included. The diagnostic yield of different strategies (dual screening with tuberculin skin test [TST] and interferon-?-release assay [IGRA], two-step TST, and early screening performed at least 12 months before starting biological treatment) was analyzed. (3) Results: Out of 7594 screened patients, 1445 (19%; 95% CI 18-20%) had LTBI. Immunomodulator (IMM) treatment at screening decreased the probability of detecting LTBI (20% vs. 17%, p = 0.001). Regarding screening strategies, LTBI was more frequently diagnosed by dual screening than by a single screening strategy (IGRA, OR 0.60; 95% CI 0.50-0.73, p < 0.001; TST, OR 0.76; 95% CI 0.66-0.88, p < 0.001). Two-step TST increased the diagnostic yield of a single TST by 24%. More cases of LTBI were diagnosed by early screening than by routine screening before starting anti-TNF agents (21% [95% CI 20-22%] vs. 14% [95% CI 13-16%], p < 0.001). The highest diagnostic performance for LTBI (29%) was obtained by combining early and TST/IGRA dual screening strategies in patients without IMM. (4): Conclusions: Both early screening and TST/IGRA dual screening strategies significantly increased diagnostic performance for LTBI in patients with IBD, with optimal performance achieved when they are used together in the absence of IMM.
Fuente: Journal of clinical medicine 2022, 11, 3915
Publisher: MDPI
Publication date: 05/07/2022
No. of pages: 12
Publication type: Article
DOI: 10.3390/jcm11133915
ISSN: 2077-0383
Publication Url: https://doi.org/10.3390/jcm11133915
Citations in Scopus
Citations in Google Scholar
Other metrics in Scopus
Consult in Scopus
Read publication
RIESTRA, SABINO
TAXONERA, CARLOS
ZABANA, YAMILE
CARPIO, DANIEL
CHAPARRO, MARÍA
BARRIO, JESÚS
MONTSERRAT RIVERO TIRADO
LÓPEZ-SANROMÁN, ANTONIO
ESTEVE, MARÍA
FRANCISCO, RUTH DE
BASTIDA, GUILLERMO
GARCÍA-LÓPEZ, SANTIAGO
MAÑOSA, MIRIAM
MARTÍN-ARRANZ, MARÍA DOLORES
PÉREZ-CALLE, JOSÉ LÁZARO
GUARDIOLA, JORDI
MUÑOZ, FERNANDO
ARRANZ, LAURA
CABRIADA, JOSÉ LUIS
GARCÍA-SEPULCRE, MARIANA
Back