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New perspectives for the rescue of cognitive disability in Down syndrome

Abstract: Down syndrome (DS) is a relatively common genetic condition caused by the triplication of human chromosome 21. No therapies currently exist for the rescue of neurocognitive impairment in DS. This review presents exciting findings showing that it is possible to restore brain development and cognitive performance in mouse models of DS with therapies that can also apply to humans. This knowledge provides a potential breakthrough for the prevention of intellectual disability in DS.

 Fuente: Journal of Neuroscience, 2015, 35(41), 13843-13852

 Publisher: Society for Neuroscience

 Publication date: 14/10/2015

 No. of pages: 10

 Publication type: Article

 DOI: 10.1523/JNEUROSCI.2775-15.2015

 ISSN: 0270-6474,1529-2401

 Publication Url: https://doi.org/10.1523/JNEUROSCI.2775-15.2015

Authorship

BARTESAGHI, RENATA

HAYDAR, TARIK F.

DELABAR, JEAN MAURICE

DIERSSEN, MARA

BIANCHI, DIANA W.