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Abstract: Down syndrome (DS) is a relatively common genetic condition caused by the triplication of human chromosome 21. No therapies currently exist for the rescue of neurocognitive impairment in DS. This review presents exciting findings showing that it is possible to restore brain development and cognitive performance in mouse models of DS with therapies that can also apply to humans. This knowledge provides a potential breakthrough for the prevention of intellectual disability in DS.
Fuente: Journal of Neuroscience, 2015, 35(41), 13843-13852
Publisher: Society for Neuroscience
Publication date: 14/10/2015
No. of pages: 10
Publication type: Article
DOI: 10.1523/JNEUROSCI.2775-15.2015
ISSN: 0270-6474,1529-2401
Publication Url: https://doi.org/10.1523/JNEUROSCI.2775-15.2015
Consult in UCrea Read publication
BARTESAGHI, RENATA
HAYDAR, TARIK F.
DELABAR, JEAN MAURICE
DIERSSEN, MARA
CARMEN MARTINEZ-CUE PESINI
BIANCHI, DIANA W.
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