Early postnatal oleic acid administration enhances synaptic development and cognitive abilities in the Ts65Dn mouse model of Down syndrome

Article

Nutritional Neuroscience, 2022, 25(7), 1400-1412

 Authorship: VERONICA VIDAL SANCHEZ, SUSANA GARCIA CERRO, NOEMI RUEDA REVILLA, ALBA PUENTE BEDIA, RENATA BARTESAGHI, CARMEN MARTINEZ-CUE PESINI

 2022

Fatty acids: a safe tool for improving neurodevelopmental alterations in Down syndrome?

Article

Nutrients, 2022, 14(14), 2880

 Authorship: CARMEN MARTINEZ-CUE PESINI, RENATA BARTESAGHI

 2022

Oxidative-stress-associated proteostasis disturbances and increased DNA damage in the hippocampal granule cells of the Ts65Dn model of Down syndrome

Article

Antioxidants 2022, 11(12), 2438

 Authorship: ALBA PUENTE BEDIA, MARIA TERESA BERCIANO BLANCO, CARMEN MARTINEZ-CUE PESINI, MIGUEL ANGEL LAFARGA COSCOJUELA, NOEMI RUEDA REVILLA

 01/12/2022

Down syndrome is an oxidative phosphorylation disorder

Article

Redox Biology, 2021, 41, 101871

 Authorship: M PILAR BAYONA-BAFALUY, NURIA GARRIDO-PÉREZ, PATRICIA MEADE, ELDRIS IGLESIAS, IRENE JIMÉNEZ-SALVADOR, JULIO MONTOYA, CARMEN MARTINEZ-CUE PESINI, EDUARDO RUIZ-PESINI

 2021

Bexarotene impairs cognition and produces hypothyroidism in a mouse model of Down Syndrome and Alzheimer's disease

Article

Frontiers in Pharmacology, 2021, 12, 613211

 Authorship: VERÓNICA VIDAL, ALBA PUENTE BEDIA, SUSANA GARCÍA-CERRO, MARIA TERESA GARCIA UNZUETA, NOEMI RUEDA REVILLA, JAVIER RIANCHO ZARRABEITIA, CARMEN MARTINEZ-CUE PESINI

 2021

Nuclear reorganization in hippocampal granule cell neurons from a mouse model of Down syndrome: changes in chromatin configuration, nucleoli and Cajal Bodies

Article

International Journal of Molecular Sciences, 2021, 22(3), 1259

 Authorship: ALBA PUENTE BEDIA, MARIA TERESA BERCIANO BLANCO, OLGA TAPIA MARTINEZ, CARMEN MARTINEZ-CUE PESINI, MIGUEL ANGEL LAFARGA COSCOJUELA, NOEMI RUEDA REVILLA

 2021

Prenatal administration of oleic acid or linolenic acid reduces neuromorphological and cognitive alterations in Ts65dn Down syndrome mice

Article

The Journal of Nutrition, 2020, 150(6), 1631-1643

 Authorship: SUSANA GARCIA CERRO, NOEMI RUEDA REVILLA, VERONICA VIDAL SANCHEZ, ALBA PUENTE BEDIA, VÍCTOR MANUEL CAMPA FERNÁNDEZ, SARA LANTIGUA ROMERO, JOSEP ORIOL NARCIS MAJOS, ANA VELASCO, RENATA BARTESAGHI, CARMEN MARTINEZ-CUE PESINI

 01/06/2020

Prenatal, but not postnatal, curcumin administration rescues neuromorphological and cognitive alterations in Ts65Dn Down syndrome mice

Article

The Journal of Nutrition, 2020, 150(9), 2478-2489

 Authorship: NOEMI RUEDA REVILLA, VERONICA VIDAL SANCHEZ, SUSANA GARCIA CERRO, ALBA PUENTE BEDIA, VÍCTOR MANUEL CAMPA FERNÁNDEZ, SARA LANTIGUA ROMERO, JOSEP ORIOL NARCIS MAJOS, RENATA BARTESAGHI, CARMEN MARTINEZ-CUE PESINI

 01/09/2020

Signalling pathways implicated in Alzheimer's disease neurodegeneration in individuals with and without Down syndrome

Article

International Journal of Molecular Sciences, 2020, 21(18), 6906

 Authorship: CARMEN MARTINEZ-CUE PESINI, NOEMI RUEDA REVILLA

 2020

Cellular senescence in neurodegenerative diseases

Article

Frontiers in Cellular Neuroscience, 2020, 14, 16

 Authorship: CARMEN MARTINEZ-CUE PESINI, NOEMI RUEDA REVILLA

 2020

Antioxidants in Down Syndrome: from preclinical studies to clinical trials

Article

Antioxidants, 2020, 9(8), 692

 Authorship: NOEMI RUEDA REVILLA, CARMEN MARTINEZ-CUE PESINI

 2020

Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome

Book part

Preclinical research in Down syndrome: insights for pathophysiology and treatments

 Authorship: CARMEN MARTINEZ-CUE PESINI, MARA DIERSSEN

 2020

Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome

Book part

Preclinical research in Down syndrome: insights for pathophysiology and treatments

 Authorship: NOEMI RUEDA REVILLA, JESUS FLOREZ BELEDO, MARA DIERSSEN, CARMEN MARTINEZ-CUE PESINI

 2020

Decreasing the expression of GABAA[alfa]5 subunit-containing receptors partially improves cognitive, electrophysiological, and morphological hippocampal defects in the Ts65Dn model of Down syndrome

Article

Molecular Neurobiology, 2018, 55(6), 4745-4762

 Authorship: VERONICA VIDAL SANCHEZ, SUSANA GARCÍA CERRO, PAULA MARTINEZ FERNANDEZ, ANDREA CORRALES PARDO, SARA LANTIGUA ROMERO, REBECA VIDAL CASADO, NOEMI RUEDA REVILLA, LAURENCE OZMEN, MARIA CLEMENCIA HERNÁNDEZ, CARMEN MARTINEZ-CUE PESINI

 01/06/2018

Treatment with corn oil improves neurogenesis and cognitive performance in the Ts65Dn mouse model of Down syndrome

Article

Brain Research Bulletin, 2018, 140, 378-391

 Authorship: ANDREA GIACOMINI, FIORENZA STAGNI, MARCO EMILI, SANDRA GUIDI, MARIA ELISA SALVALAI, MARIAGRAZIA GRILLI, VERONICA VIDAL SANCHEZ, CARMEN MARTINEZ-CUE PESINI, RENATA BARTESAGHI

 01/06/2018

Anti-IL17 treatment ameliorates Down syndrome phenotypes in mice

Article

Brain, Behavior and Immunity, 2018, 73, 235-251

 Authorship: NOEMI RUEDA REVILLA, VERONICA VIDAL SANCHEZ, SUSANA GARCIA CERRO, JOSEP ORIOL NARCIS MAJOS, MARÍA LLORENS MARTÍN, ANDREA CORRALES PARDO, SARA LANTIGUA ROMERO, MARCOS IGLESIAS, JESUS MERINO PEREZ, RAMON MERINO PEREZ, CARMEN MARTINEZ-CUE PESINI

 01/10/2018

Cerebellar alterations in a model of Down syndrome: the role of the Dyrk1A gene

Article

Neurobiology of Disease, 2018, 110, 206-217

 Authorship: SUSANA GARCIA CERRO, VERONICA VIDAL SANCHEZ, SARA LANTIGUA ROMERO, MARIA TERESA BERCIANO BLANCO, MIGUEL ANGEL LAFARGA COSCOJUELA, PEDRO RAMOS CABRER, DANIEL PADRO, NOEMI RUEDA REVILLA, CARMEN MARTINEZ-CUE PESINI

 01/02/2018

The GABAA[alfa]5-selective modulator, RO4938581, rescues protein anomalies in the Ts65Dn mouse model of Down syndrome

Article

Neuroscience, 2018, 372, 192-212

 Authorship: A. BLOCK, MD. M. AHMED, NOEMI RUEDA REVILLA, M.C. HERNÁNDEZ, CARMEN MARTINEZ-CUE PESINI, K. J. GARDINER

 21/02/2018

Clinical uses of melatonin in neurological diseases and mental and behavioural disorders

Article

Current Medicinal Chemistry, 2017, 24(35), 3851-3878

 Authorship: EMILIO JOSE SANCHEZ BARCELO, NOEMI RUEDA REVILLA, MARIA DOLORES MEDIAVILLA AGUADO, CARMEN MARTINEZ-CUE PESINI, R.J. REITER

 2017

Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes

Article

Neurobiology of Disease, 2017, 106, 76-88

 Authorship: SUSANA GARCÍA CERRO, NOEMI RUEDA REVILLA, VERONICA VIDAL SANCHEZ, SARA LANTIGUA ROMERO, CARMEN MARTINEZ-CUE PESINI

 21/06/2017

Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome

Article

Behavioural Brain Research, 2017, 334, 142-154

 Authorship: ANDREA CORRALES PARDO, EDUARDO B. PARISOTTO, VERONICA VIDAL SANCHEZ, SUSANA GARCIA CERRO, SARA LANTIGUA ROMERO, MARIAN DIEGO, DANILO WILHEM FILHO, EMILIO JOSE SANCHEZ BARCELO, CARMEN MARTINEZ-CUE PESINI, NOEMI RUEDA REVILLA

 2017

The relationship between behavior acquisition and persistence abilities: involvement of adult hippocampal neurogenesis

Article

Hippocampus, 2016, 26(7), 857-874

 Authorship: SIMONA GRADARI, PALOMA PÉREZ DOMPER, RAY G. BUTLER, CARMEN MARTINEZ-CUE PESINI, GONZALO G. DE POLAVIEJA, JOSÉ LUIS TREJO

 2016

Chronic melatonin administration reduced oxidative damage and cellular senescence in the hippocampus of a mouse model of Down syndrome

Article

Neurochemical Research, 2016, 41(11), 2904-2913

 Authorship: EDUARDO B. PARISOTTO, VERONICA VIDAL SANCHEZ, SUSANA GARCIA CERRO, SARA LANTIGUA ROMERO, DANILO WILHELM FILHO, EMILIO JOSE SANCHEZ BARCELO, CARMEN MARTINEZ-CUE PESINI, NOEMI RUEDA REVILLA

 2016

New perspectives for the rescue of cognitive disability in Down syndrome

Article

Journal of Neuroscience, 2015, 35(41), 13843-13852

 Authorship: RENATA BARTESAGHI, TARIK F. HAYDAR, JEAN MAURICE DELABAR, MARA DIERSSEN, CARMEN MARTINEZ-CUE PESINI, DIANA W. BIANCHI

 14/10/2015

AUTOCLAVE Y CESTILLO INOXIDABLE (FINANCIADA POR LA CONSEJERÍA DE UNIVERSIDADES, IGUALDAD, CULTURA Y DEPORTE DEL GOBIERNO DE CANTABRIA (CONTRATO PROGRAMA GOBIERNO DE CANTABRIA ? UC).)

 Plasticidad Tisular Patológica

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: MARIA AMOR HURLE GONZALEZ

Typology: Complementary actions and Infrastructures

Start year: 2022

REVERSIÓN DE LA DISFUNCIÓN MITOCONDRIAL COMO HERRAMIENTA TERAPÉUTICA PARA PALIAR LA NEUROPATOLOGÍA DEL SÍNDROME DE DOWN Y LA ENFERMEDAD DE ALZHEIMER. Proyecto PID2020-117601RB-I00 financiado por MICIU/AEI /10.13039/501100011033

 Neurobiología Del Aprendizaje

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Competitive national public projects

Start year: 2021

TRATAMIENTOS TEMPRANOS Y TARDÍOS PARA PALIAR LAS ALTERACIONES COGNITIVAS Y NEUROPATOLÓGICAS ASOCIADAS A LA ENFERMEDAD DE ALZHEIMER EN EL SÍNDROME DE DOWN. (CONSEJERÍA DE UNIVERSIDADES, IGUALDAD, CULTURA Y DEPORTE DEL GOBIERNO DE CANTABRIA)

 Neurobiología Del Aprendizaje

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Agreements and contracts art.83, University and Competitive Chairs UC

Start year: 2020

NEURODEGENERATIVE MECHANISMS IN DOWN SYNDROME: DNA DAMAGE ACCUMULATION AND PROTEOSTASIS DISRUPTION

 Neurobiología Del Aprendizaje

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: NOEMI RUEDA REVILLA

Typology: Agreements and contracts art.83, University and Competitive Chairs UC

Start year: 2019

MICROTOMO DE VIBRACIÓN PARA MUESTRAS BIOLÓGICAS

 Apoptosis I

 DEPARTAMENTO DE ANATOMÍA Y BIOLOGÍA CELULAR

Head: JUAN MARIO HURLE GONZALEZ

Typology: Complementary actions and Infrastructures

Start year: 2017

ESTRATEGIAS TERAPÉUTICAS PARA PALIAR EL DETERIORO COGNITIVO ENCONTRADO ANTES Y DESPUÉS DE LA APARICIÓN DE PATOLOGÍA TIPO ALZHEIMER EN UN MODELO ANIMAL DE SÍNDROME DE DOWN (PSI2016-76194-R) (AEI/FEDER, UE)

 Neurobiología Del Aprendizaje

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Competitive national public projects

Start year: 2016

EVALUACIÓN DE DISTINTAS ESTRATEGÍAS TERAPÉUTICAS BASADAS EN INMUNOTERAPIA EN MODELOS ANIMALES DE SÍNDROME DE DOWN Y DE ENFERMEDAD DE ALZHEIMER

 Neurobiología Del Aprendizaje

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Agreements and contracts art.83, University and Competitive Chairs UC

Start year: 2016

EFECTOS DE LA NORMALIZACIÓN DEL NÚMERO DE COPIAS DE DYRK1A SOBRE FENOTIPOS CEREBRALES ALTERADOS Y LOS PROCESOS NEURODEGENERATIVOS EN UN MODELO DE SINDROME DE DOWN

 Neurobiología Del Aprendizaje

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Heads: CARMEN MARTINEZ-CUE PESINI, NOEMI RUEDA REVILLA

Typology: Competitive private projects, competitive autonomic and subcon…

Start year: 2016

EFFECTS OF THE NORMALIZATION OF DYRK1A COPY NUMBER ON THE CEREBELLAR PHENOTYPES AND NEURODEGENERATIVE PROFILE OF A MOUSE MODEL OF DOWN SYNDROME

 Neurobiología Del Aprendizaje

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: NOEMI RUEDA REVILLA

Typology: Competitive private projects, competitive autonomic and subcon…

Start year: 2016

NEW AVENUES FOR THE RESCUE OF INTELLECTUAL DISABILITY IN DOWN SYNDROME

 Neurobiología Del Aprendizaje

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Competitive private projects, competitive autonomic and subcon…

Start year: 2015

INVESTIGATING THE INVOLVEMENT OF GABAA 5 SUB-UNIT-CONTAINING RECEPTORS IN ASD PHENOTYPES

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Agreements and contracts art.83, University and Competitive Chairs UC

Start year: 2015

EFFECTS OF CHRONIC MELATONIN ADMINISTRATION ON THE NEURODEVELOPMENTAL ALTERATIONS AND NEURODEGENERATION IN A MOUSE MODEL OF DOWN SYNDROME

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: NOEMI RUEDA REVILLA

Typology: Competitive private projects, competitive autonomic and subcon…

Start year: 2013

DÉFICITS COGNITIVOS DEL RATÓN Ts65Dn, UN MODELO DE SÍNDROME DE DOWN: DIANAS TERAPÉUTICAS FRENTE A LOS MECANISMOS IMPLICADOS EN LAS ALTERACIONES DEL HIPOCAMPO Y DEL CEREBELO (PSI2012-33652)

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Competitive national public projects

Start year: 2013

ELECTROPHYSIOLOGICAL STUDIES IN TS65Dn MICE AFTER CHRONIC TREATMENT WITH GABA A ?5 NEGATIVE ALLOSTERIC MODULATORS

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Agreements and contracts art.83, University and Competitive Chairs UC

Start year: 2012

THE DOSE-RESPONSE EFFECT OF GABAA ?5 NAM CHRONIC TREATMENT IN JUVENILE DOWN SYNDROME MICE: BEHAVIORAL, PATHOPHYSIOLOGICAL AND BIOMARKER ANALYSIS

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Agreements and contracts art.83, University and Competitive Chairs UC

Start year: 2012

EFECTO DE DIVERSOS FÁRMACOS SOBRE EL COMPORTAMIENTO EN UN MODELO MURINO DE ENFERMEDAD DE ALZHEIMER

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Agreements and contracts art.83, University and Competitive Chairs UC

Start year: 2012

INHIBICIÓN FARMACOLÓGICA Y GENÉTICA DEL RECEPTOR ALFA5-GABAA E INHIBICIÓN DEL GEN DYRK1A EN EL MODELO MURINO DE SÍNDROME DE DOWN TS65DN: ACCIÓN TERAPÉUTICA (BFU2011-24755)

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Competitive national public projects

Start year: 2012

STUDY OF THE EFFECT OF CHRONIC ADMINISTRATION OF A NOVEL GABA-A 5 INVERSE AGONIST, R2, ON THE CONGNITIVE, ELECTROPHYSILOGICAL AND NEUROMORPHOLOGICAL DEFICITS FOUND IN THE TS65DN MOUSE, A MODEL OF DOWN SYNDRME

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Agreements and contracts art.83, University and Competitive Chairs UC

Start year: 2011

Study of the effect of postnatal administration of GABA-A ?5 inverse agonists,, RO4938581 and R1, on the cognitive, electrophysiological and neuromorphological deficits found in the Ts65Dn mouse, a model of Down Syndrome

 DEPARTAMENTO DE FISIOLOGÍA Y FARMACOLOGÍA

Head: CARMEN MARTINEZ-CUE PESINI

Typology: Agreements and contracts art.83, University and Competitive Chairs UC

Start year: 2010

Alteraciones celulares asociadas al exceso de dosis génica o de estrés oxidativo en las células granulares del hipocampo de un modelo de síndrome de Down

 Authorship: ALBA PUENTE BEDIA

 Supervision: CARMEN MARTINEZ-CUE PESINI , NOEMI RUEDA REVILLA 

 Defense date: 25/10/2022

Efecto de la Administración de Moduladores Alostéricos Negativos Selectivos para la Subunidad GABAa@5 sobre los Procesos Cognitivos Implicados en las Alteraciones de Aprendizaje y Memoria de un Modelo de Síndrome de Down

 Authorship: MARIA ANGELES DIEGO MANTECON

 Supervision: JOSE ANTONIO DEL BARRIO DEL CAMPO, CARMEN MARTINEZ-CUE PESINI 

 Defense date: 17/07/2017

Efecto de Distintas Estrategias Terapéuticas sobre los Déficits Cognitivos y las Alteraciones Neuromorfológicas de un Modelo de Síndrome de Down

 Authorship: SARA LANTIGUA ROMERO

 Supervision: CARMEN MARTINEZ-CUE PESINI , NOEMI RUEDA REVILLA 

 Defense date: 14/07/2017

Efecto de la Reducción de la Inhibición Mediada por los Receptores GABAAa5 y GABAb sobre las Alteraciones Funcionales y Neuromorfológicas en un Modelo de Síndrome de Down

 Authorship: VERONICA VIDAL SANCHEZ

 Supervision: CARMEN MARTINEZ-CUE PESINI 

 Defense date: 07/04/2017

Estudio del Efecto de la Reducción del Número de Copias del Gen Dyrk1A sobre Distintos Fenotipos Funcionales y Neuromorfológicos Encontrados en un Modelo Murino de Síndrome de Down y en Ratones Euploides

 Authorship: SUSANA GARCIA CERRO

 Supervision: CARMEN MARTINEZ-CUE PESINI , NOEMI RUEDA REVILLA 

 Defense date: 25/03/2015

Estudio del Efecto de la Administración Crónica de Fármacos Agonistas Inversos Selectivos para la Subunidad alfa5 del Receptor GABAa sobre los Déficits Cognitivos, Electrofisiológicos y Neuromorfológicos del Ratón Ts65Dn, un Modelo Murino de Síndrome de Down

 Authorship: PAULA MARTINEZ FERNANDEZ

 Supervision: CARMEN MARTINEZ-CUE PESINI 

 Defense date: 01/07/2014

Estudio del Efecto de Distintas Estrategias Terapéuticas Farmacológicas sobre las Alteraciones Cognitivas y Neuromorfológicas del Ratón Ts65Dn, un Modelo Murino de Sindrome de Down.

 Authorship: NOEMI RUEDA REVILLA

 Supervision: JESUS FLOREZ BELEDO, CARMEN MARTINEZ-CUE PESINI 

 Defense date: 15/04/2008

Neurotoxicidad y Alteraciones Cognitivo-Conductuales Derivadas del Tratamiento Crónico con Opioides.

 Authorship: MONICA TRAMULLAS FERNANDEZ

 Supervision: MARIA AMOR HURLE GONZALEZ , CARMEN MARTINEZ-CUE PESINI 

 Defense date: 08/11/2006

Data from: overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome

Dataset

 DOI: 10.5061/dryad.p5614

 Authorship: SUSANA GARCIA CERRO, PAULA MARTINEZ FERNANDEZ, VERONICA VIDAL SANCHEZ, ANDREA CORRALES PARDO, JESUS FLOREZ BELEDO, REBECA VIDAL CASADO, NOEMI RUEDA REVILLA, MARÍA LOURDES ARBONÉS DE RAFAEL, CARMEN MARTINEZ-CUE PESINI

 01/08/2015