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Increased risk of MAFLD and liver fibrosis in inflammatory bowel disease Independent of classic metabolic risk factors

Abstract: Background & Aims: There is conflicting evidence regarding the prevalence of and risk factors for metabolic-associated fatty liver disease (MAFLD) in patients with inflammatory bowel disease (IBD). We aimed to determine MAFLD prevalence and risk factors in IBD patients. Methods: Cross-sectional, case-control study included all consecutive IBD patients treated at 2 different university hospitals. Controls were subjects randomly selected from the general population and matched by age, sex, type 2 diabetes status, and body mass index in a 1:2 ratio. MAFLD was confirmed by controlled attenuation parameter. Liver biopsies were collected when MAFLD with significant liver fibrosis was suspected. In addition, age- and fibrosis stage?paired non-IBD patients with biopsy-proven MAFLD served as a secondary control group. Results: Eight hundred thirty-one IBD patients and 1718 controls were included. The prevalence of MAFLD and advanced liver fibrosis (transient elastography ?9.7 kPa) was 42.00% and 9.50%, respectively, in IBD patients and 32.77% and 2.31%, respectively, in the general population (P < .001). A diagnosis of IBD was an independent predictor of MAFLD (adjusted odds ratio, 1.99; P < .001) and an independent risk factor for advanced liver fibrosis (adjusted odds ratio, 5.55; P < .001). Liver biopsies were obtained from 40 IBD patients; MAFLD was confirmed in all cases, and fibrosis of any degree was confirmed in 25 of 40 cases (62.5%). Body mass index and type 2 diabetes prevalence were significantly lower in IBD-MAFLD patients than in severity-paired patients with biopsy-proven MAFLD. Conclusions: MAFLD and liver fibrosis are particularly prevalent in IBD patients, regardless of the influence of classic metabolic risk factors.

 Authorship: Juan Carlos Rodriguez-Duque, José Luis Calleja, Paula Iruzubieta, Marta Hernández-Conde, Coral Rivas-Rivas, María Isabel Vera, Maria Jose Garcia, Marta Pascua, Beatriz Castro, Agustín García-Blanco, Enrique García-Nieto, Soraya Curiel-del Olmo, María Luisa Cagigal, Lorena Lopez-Montejo, Tatiana Fernández-Lamas, Laura Rasines, José Ignacio Fortea, José Pedro Vaque, Yza Frias, Montserrat Rivero, María Teresa Arias-Loste and Javier Crespo

 Fuente: Clinical Gastroenterology and Hepatology, 2023, 21(2), 406-414

 Publisher: Elsevier

 Year of publication: 2023

 No. of pages: 16

 Publication type: Article

 DOI: 10.1016/j.cgh.2022.01.039

 ISSN: 1542-3565,1542-7714

 Publication Url: https://doi.org/10.1016/j.cgh.2022.01.039

Authorship

RODRÍGUEZ-DUQUE, JUAN CARLOS

CALLEJA, JOSÉ LUIS

PAULA IRUZUBIETA COZ

HERNÁNDEZ-CONDE, MARTA

RIVAS-RIVAS, CORAL

VERA, MARÍA ISABEL

GARCÍA, MARÍA JOSÉ

PASCUAL, MARTA

CASTRO, BEATRIZ

AGUSTIN GARCIA BLANCO

GARCÍA-NIETO, ENRIQUE

SORAYA CURIEL DEL OLMO

MARIA LUISA CAGIGAL COBO

LÓPEZ-MONTEJO, LORENA

FERNÁNDEZ-LAMAS, TATIANA

RASINES, LAURA

JOSE IGNACIO FORTEA ORMAECHEA

FRÍAS, YZA

MONTSERRAT RIVERO TIRADO

JAVIER CRESPO GARCIA