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Abstract: Background & aims: Non-alcoholic fatty liver disease (NAFLD) has become a major public health problem, but the prevalence of fibrosis associated with non-alcoholic steatohepatitis (NASH) is largely unknown in the general population. This study aimed to provide an updated estimation of the prevalence of NASH fibrosis in Spain. Methods: This was an observational, retrospective, cross-sectional, population-based study with merged data from two Spanish datasets: a large (N = 12 246) population-based cohort (ETHON), including transient elastography (TE) data, and a contemporary multi-centric biopsy-proven NASH cohort with paired TE data from tertiary centres (N = 501). Prevalence for each NASH fibrosis stage was estimated by crossing TE data from ETHON dataset with histology data from the biopsy-proven cohort. Results: From the patients with valid TE in ETHON dataset (N = 11 440), 5.61% (95% confidence interval [95% CI]: 2.53-11.97) had a liver stiffness measurement (LSM) ? 8 kPa. The proportion attributable to NAFLD (using clinical variables and Controlled Attenuation Parameter) was 57.3% and thus, the estimated prevalence of population with LSM ? 8 kPa because of NAFLD was 3.21% (95% CI 1.13-8.75). In the biopsy-proven NASH cohort, 389 patients had LSM ? 8 kPa. Among these, 37% did not have significant fibrosis (F2-4). The estimated prevalence of NASH F2-3 and cirrhosis in Spain's adult population were 1.33% (95% CI 0.29-5.98) and 0.70% (95% CI 0.10-4.95) respectively. Conclusions: These estimations provide an accurate picture of the current prevalence of NASH-related fibrosis in Spain and can serve as reference point for dimensioning the therapeutic efforts that will be required as NASH therapies become available.
Fuente: Liver International. 2022;42:1783-1792
Publisher: Wiley-Blackwell
Publication date: 01/08/2022
No. of pages: 10
Publication type: Article
DOI: 10.1111/liv.15323
ISSN: 1478-3223,1478-3231
Publication Url: https://doi.org/10.1111/liv.15323
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CALLEJA, JOSÉ L.
RIVERA-ESTEBAN, JESÚS
ALLER, ROCÍO
HERNÁNDEZ-CONDE, MARTA
ABAD, JAVIER
PERICÀS, JUAN M.
BENITO, HUGO G.
SERRA, MIGUEL A.
ESCUDERO, AMPARO
AMPUERO, JAVIER
LUCENA, ANA
SÁNCHEZ, YOLANDA
MARIA TERESA ARIAS LOSTE
PAULA IRUZUBIETA COZ
ROMERO-GÓMEZ, MANUEL
SALVADOR, AUGUSTÍN
JAVIER CRESPO GARCIA
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