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The role of HBIG in real life for patients undergoing liver transplantation due to HDV-related cirrhosis

Abstract: Recommended post-liver transplant (LT) prophylaxis in patients with hepatitis delta includes a nucleos(t)ide analogue (NA) and anti-hepatitis B immunoglobulin (HBIG) indefinitely. We analysed the use of HBIG in real-life clinical practice and its impact on HBV/HDV recurrence in 174 HDV-related LT patients from 10 Spanish liver transplant centres (1988-2018). Median post-LT follow-up was 7.8 (2.3-15.1) years and patient survival at 5 years was 90%. Most patients (97%) received HBIG in the immediate post-LT, but only 42% were on HBIG at the last control. Among those discontinuing HBIG, the median time on treatment was 18 (7-52) months. Post-LT HBsAg+ was detected in 16 (9%) patients and HBV-DNA in 12 (7%). Despite HBsAg positivity, HDV recurrence was reported only in three patients (1.7%), all of whom were not receiving NA and had discontinued HBIG. Our data suggest that a finite HBIG prophylaxis in HDV-LT is feasible, especially if high-barrier NAs are used.

 Fuente: Liver International, 2024, 44, 279-285

 Publisher: Wiley-Blackwell

 Year of publication: 2024

 No. of pages: 7

 Publication type: Article

 DOI: 10.1111/liv.15777

 ISSN: 1478-3223,1478-3231

 Publication Url: https://doi.org/10.1111/liv.15777

Authorship

RODRÍGUEZ-TAJES, SERGIO

GARCÍA-ELIZ, MARÍA

CABALLERO MARCOS, ARANTXA

CAMPOS-VARELA, ISABEL

CACHERO ROS, ALBA

LOINAZ, CARMELO

GÓMEZ BRAVO, MIGUEL Á.

RODRÍGUEZ-PERÁLVAREZ, MANUEL

GONZÁLEZ DIÉGUEZ, MARÍA L.

VINAIXA, CARMEN

PASCASIO, JOSÉ M.

FERNÁNDEZ VÁZQUEZ, INMACULADA

BALIELLAS, CARMEN

CASTELLS, LLUIS

SALCEDO, MAGDALENA

PRIETO, MARTÍN

CRESPO, GONZALO

LENS, SABELA

FORNS, XAVIER