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Abstract: Background: MOTS-c and Romo1 are mitochondrial peptides that are modulated by oxidative stress. No previous studies have explored circulating levels of MOTS-c in patients with chronic obstructive pulmonary disease (COPD). Methods: We enrolled 142 patients with stable COPD and 47 smokers with normal lung function in an observational cross-sectional study. We assessed serum levels of both MOTS-c and Romo1 and associated these findings with clinical characteristics of COPD. Results: Compared with smokers with normal lung function, patients with COPD had lower levels of MOTS-c (p = 0.02) and higher levels of Romo1 (p = 0.01). A multivariate logistic regression analysis revealed that above-median MOTS-c levels were positively associated with Romo1 levels (OR 1.075, 95% CI 1.005?1.150, p = 0.036), but no association was found with other COPD characteristics. Below-median levels of circulating MOTS-c were associated with oxygen desaturation (OR 3.25 95% CI 1.456?8.522, p = 0.005) and walking <350 meters (OR 3.246 95% CI 1.229?8.577, p = 0.018) in six-minute walk test. Above-median levels of Romo1 were positively associated with current smoking (OR 2.756, 95% CI 1.133?6.704, p = 0.025) and negatively associated with baseline oxygen saturation (OR 0.776 95% CI 0.641?0.939, p = 0.009). Conclusions: Reduced levels of circulating MOTS-c and increased levels of Romo1 were detected in patients diagnosed with COPD. Low levels of MOTS-c were associated with oxygen desaturation and poorer exercise capacity using 6 min walk test. Romo1 was associated with current smoking and baseline oxygen saturation.
Fuente: Frontiers in Medicine, 2023, 10, 1100211
Publisher: Frontiers Media S.A.
Year of publication: 2023
No. of pages: 9
Publication type: Article
DOI: 10.3389/fmed.2023.1100211
ISSN: 2296-858X
Spanish project: PT17/0015/0019
Publication Url: https://doi.org/10.3389/fmed.2023.1100211
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CARLOS ANTONIO AMADO DIAGO
MARTÍN-AUDERA, PAULA
AGÜERO, JUAN
BERNARDO ALIO LAVIN GOMEZ
ARMANDO RAUL GUERRA RUIZ
BOUCLE, DAYMARA
DIEGO JOSE FERRER PARGADA
BERJA, ANA
MARTÍN, FERNANDO
CASANOVA, CIRO
MARIA TERESA GARCIA UNZUETA
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