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Abstract: Introduction: Whole-body autopsies may be crucial to understand coronavirus disease 2019 (COVID-19) pathophysiology. We aimed to analyze pathological findings in a large series of full-body autopsies, with a special focus on superinfections. Methods: This was a prospective multicenter study that included 70 COVID-19 autopsies performed between April 2020 and February 2021. Epidemiological, clinical and pathological information was collected using a standardized case report form. Results: Median (IQR) age was 70 (range 63.75?74.25) years and 76% of cases were males. Most patients (90%,) had at least one comorbidity prior to COVID-19 diagnosis, with vascular risk factors being the most frequent. Infectious complications were developed by 65.71% of the patients during their follow-up. Mechanical ventilation was required in most patients (75.71%) and was mainly invasive. In multivariate analyses, length of hospital stay and invasive mechanical ventilation were significantly associated with infections (p?=?0.036 and p?=?0.013, respectively). Necropsy findings revealed diffuse alveolar damage in the lungs, left ventricular hypertrophy in the heart, liver steatosis and pre-infection arteriosclerosis in the heart and kidneys. Conclusion: Our study confirms the main necropsy histopathological findings attributed to COVID-19 in a large patient series, while underlining the importance of both comorbid conditions and superinfections in the pathology.
Fuente: Frontiers in Medicine, 2023, 10, 1151843
Publisher: Frontiers Media S.A.
Year of publication: 2023
No. of pages: 11
Publication type: Article
DOI: 10.3389/fmed.2023.1151843
ISSN: 2296-858X
Publication Url: https://doi.org/10.3389/fmed.2023.1151843
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CÁCERES, INMACULADA
HERMIDA ROMERO, TERESA
GUERRA MERINO, ISABEL
PORTU ZAPIRAIN, JOSEBA
PÉREZ-MIES, BELÉN
SÁNCHEZ-CONDE, MATILDE
ALONSO RIAÑO, MARINA
RUBIO, RAFAEL
FORTÉS ALEN, JOSÉ
VIDAL GONZÁLEZ, ÁNXELA
SALAS ANTÓN, CLARA
MÚÑEZ, ELENA
SÁNCHEZ SÁNCHEZ, RAFAEL
CORONA-MATA, DIANA
ALDECOA ANSORREGUI, IBAN
MIRÓ, JOSÉ M.
BELOQUI PÉREZ DE OBANOS, RAQUEL
JOSE JAVIER GOMEZ ROMAN
MARIA DEL CARMEN FARIÑAS ALVAREZ
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