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Abstract: The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer?s disease (rg¼ 0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
Fuente: Nature Communications, 2017, 18(8), 13624
Publisher: Nature Publishing Group
Year of publication: 2017
No. of pages: 12
Publication type: Article
DOI: 10.1038/ncomms13624
ISSN: 2041-1723
Publication Url: https://dx.doi.org/10.1038/ncomms13624
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HIBAR, DERREK P.
ADAMS, HIEAB H.H.
JAHANSHAD, NEDA
CHAUHAN, GANESH
STEIN, JASON L.
HOFER, EDITH
RENTERIA, MIGUEL E.
BIS, JOSHUA C.
ARIAS VASQUEZ, ALEJANDRO
KAMRAN IKRAM, M.
DESRIVIERES, SYLVANE
VERNOOIJ, MEIKE W.
ABRAMOVIC, LUCIJA
ALHUSAINI, SAUD
AMIN, NAJAF
ANDERSSON, MICAEL
ARFANAKIS, KONSTANTINOS
ARIBISALA, BENJAMIN S.
ROBERTO ROIZ SANTIAÑEZ
BENEDICTO CRESPO FACORRO
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