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Identification of human pathological mitral chordae tendineae using polarization-sensitive optical coherence tomography

Abstract: Defects of the mitral valve complex imply heart malfunction. The chordae tendineae (CTs) are tendinous strands connecting the mitral and tricuspid valve leaflets to the papillary muscles. These CTs are composed of organized, wavy collagen bundles, making them a strongly birefringent material. Disorder of the collagen structure due to different diseases (rheumatic, degenerative) implies the loss or reduction of tissue birefringence able to be characterized with Polarization Sensitive Optical Coherence Tomography (PS-OCT). PS-OCT is used to discriminate healthy from diseased chords, as the latter must be excised and replaced in clinical conventional interventions. PS-OCT allows to quantify birefringence reduction in human CTs affected by degenerative and rheumatic pathologies. This tissue optical property is proposed as a diagnostic marker for the identification of degradation of tendinous chords to guide intraoperative mitral valve surgery.

 Authorship: Real E., Icardo J., Fernández-Barreras G., Revuelta J., Díez M., Pontón A., Gutiérrez J., Higuera J., Conde O.,

 Fuente: Sensors, 2019, 19(3), 543

 Publisher: MDPI

 Publication date: 28/01/2019

 No. of pages: 12

 Publication type: Article

 DOI: 10.3390/s19030543

 ISSN: 1424-8220

 Spanish project: FIS2010-19860

 Publication Url: https://doi.org/10.3390/s19030543

Authorship

GASPAR FERNANDEZ BARRERAS

MARTA CALVO DIEZ

ALEJANDRO PONTON CORTINA

JOSE FRANCISCO GUTIERREZ DIEZ