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Drug weaponry to fight against SARS-CoV-2

Abstract: The current outbreak of SARS-CoV-2 virus has caused a large increase in mortality and morbidity associated with respiratory diseases. Huge efforts are currently ongoing to develop a vaccine against this virus. However, alternative approaches could be considered in the fight against this disease. Among other strategies, structural-based drug design could be an effective approach to generate specific molecules against SARS-CoV-2, thus reducing viral burden in infected patients. Here, in addition to this structural approach, we also revise several therapeutic strategies to fight against this viral threat. Furthermore, we report ACE-2 genetic polymorphic variants affecting residues involved in close contacts with SARS-CoV-2 that might be associated to different infection risks. These analyses could provide valuable information to predict the course of the disease.

 Authorship: Cabezón E., Arechaga I.,

 Fuente: Frontiers in molecular biosciences 2020; 7: 204

 Publisher: Frontiers Media

 Year of publication: 2020

 No. of pages: 11

 Publication type: Article

 DOI: 10.3389/fmolb.2020.00204

 ISSN: 2296-889X

 Publication Url: https//DOI: 10.3389/fmolb.2020.00204