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Abstract: We aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain, 2010?2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs the product of prevalence, intensity and duration of exposure to each active substance. Principal components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend; 2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA, the first component (PC1, explaining 70% of the variation) equally led by seven active substances (the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm previous associations between CLL and exposure to pesticides and provide additional evidence by application groups and active substance. However, more research is needed to disentangle independent eects of individual active substances.
Fuente: Int. J. Environ. Res. Public Health 2020, 17(14), 5174
Publisher: MDPI
Publication date: 17/07/2020
No. of pages: 11
Publication type: Article
DOI: 10.3390/ijerph17145174
ISSN: 1661-7827,1660-4601
Spanish project: PMP15/00007
Publication Url: https://doi.org/10.3390/ijerph17145174
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BENAVENTE, YOLANDA
COSTAS, LAURA
RODRÍGUEZ SUAREZ, MARTA MARIA
ALGUACIL, JUAN
MIGUEL SANTIBAÑEZ MARGÜELLO
VILA, JAVIER
ROBLES, CLAUDIA
ALONSO, ESTHER
BANDA, ESMERALDA DE LA
GONZALEZ BARCA , EVA
DIERSSEN SOTOS, TRINIDAD
GIMENO VAZQUEZ, EVA
AYMERICH, MARTA
CAMPO, ELIAS
JIMÉNEZ MOLEÓN, JOSÉ J.
MARCOS GRAGERA, RAFAEL
CASTAÑO VINYALS, GEMMA
ARAGONÉS, NURIA
POLLAN, MARINA
SANJOSE, SILVIA DE
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