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The combined use of the PLHC-1 cell line and the recombinant yeast assay to assess the environmental quality of estuarine and coastal sediments

Abstract: Sediment contamination poses a potential risk for both ecosystems and human health. Risk assessment is troublesome as sediments contain complex mixtures of toxicants, and traditional chemical analyses can neither provide information about potential hazards to organisms nor identify and measure all present contaminants. This work combines the use of the PLHC-1 cell line and the recombinant yeast assay (RYA) to assess the environmental quality of estuarine and coastal sediments. The application of multiple endpoints (cytotoxicity, generation of oxidative stress, presence of CYP1A inducing agents, micronucleus formation and estrogenicity) revealed that the organic extracts of those sediments affected by industrial activities or collected near harbours and untreated urban discharges showed significant cytotoxicity, micronuclei and CYP1A induction. The study highlights the usefulness of the applied bioassays to identify those sediments that could pose risk to aquatic organisms and that require further action to improve their environmental quality.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Marine Pollution Bulletin 2013, 77, 1-2, 282-289

Editorial: Elsevier Ltd

 Fecha de publicación: 01/12/2013

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.marpolbul.2013.09.047

ISSN: 0025-326X,1879-3363

Url de la publicación: https://doi.org/10.1016/j.marpolbul.2013.09.047

Autores/as

SCHNELL, SABINE

OLIVARES, ALBA

PIÑA, BENJAMIN

BEATRIZ ECHAVARRI ERASUN

LACORTE, SILVIA

PORTE, CINTA