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Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments

Abstract: Aquatic environments are key niches for the emergence, evolution and dissemination of antimicrobial resistance. However, the population diversity and the genetic elements that drive the dynamics of resistant bacteria in different aquatic environments are still largely unknown. The aim of this study was to understand the population genomics and evolutionary events of Escherichia coli resistant to clinically important antibiotics including aminoglycosides, in anthropogenic and natural water ecosystems. Here we show that less different E. coli sequence types (STs) are identified in wastewater than in rivers, albeit more resistant to antibiotics, and with significantly more plasmids/cell (6.36 vs 3.72). However, the genomic diversity within E. coli STs in both aquatic environments is similar. Wastewater environments favor the selection of conserved chromosomal structures associated with diverse flexible plasmids, unraveling promiscuous interplasmidic resistance genes flux. On the contrary, the key driver for river E. coli adaptation is a mutable chromosome along with few plasmid types shared between diverse STs harboring a limited resistance gene content.

 Autoría: Delgado-Blas J.F., Ovejero C.M., David S., Montero N., Calero-Caceres W., Garcillan-Barcia M.P., de la Cruz F., Muniesa M., Aanensen D.M., Gonzalez-Zorn B.,

 Fuente: Commun Biol . 2021 Apr 12;4(1):457

 Año de publicación: 2021

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s42003-021-01949-x

ISSN: 2399-3642

Proyecto español: BFU2017-86378-P

Url de la publicación: https://doi.org/10.1038/s42003-021-01949-x

Autores/as

DELGADO-BLAS, JOSE F.

OVEJERO, CRISTINA M.

DAVID, SOPHIA

MONTERO, NATALIA

CALERO-CACERES, WILLIAM

AANENSEN, DAVID M.

GONZALEZ-ZORN, BRUNO