To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of non-demented Parkinson's disease (PD) patients and compare to a control group.
The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures.
QoL was worse in PD patients (n?=?692; 62.6?±?8.9 years old, 60.3% males) than controls (n?=?206; 61?±?8.3 years old, 49.5% males): PDQ-39, 17.1?±?13.5 vs 4.4?±?6.3 (p?0.0001); PQ-10, 7.3?±?1.6 vs 8.1?±?1.2 (p?0.0001); EUROHIS-QOL8, 3.8?±?0.6 vs 4.2?±?0.5 (p?0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (r?=?0.72; p?0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r?=?0.65; p?0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (??=?0.32, 0.28, and 0.27, respectively; p?0.0001); whereas mood and gait problems contributed the most to global QoL (PQ-10, ??=?-0.46 and ?0.21, respectively; EUROHIS-QOL8, ??=?-0.44 and ?0.23, respectively).
QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients.
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