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 Detalle_Publicacion

Lung transplantation from controlled donation after circulatory death using simultaneous abdominal normothermic regional perfusion: A single center experience

Abstract: Despite the benefits of abdominal normothermic regional perfusion (A-NRP) for abdominal grafts in controlled donation after circulatory death (cDCD), there is limited information on the effect of A-NRP on the quality of the cDCD lungs. We aimed to study the effect of A-NRP in lungs obtained from cDCD and its impact on recipients´ outcomes. This is a study comparing outcomes of lung transplants (LT) from cDCD donors (September 2014 to December 2021) obtained using A-NRP as the abdominal preservation method. As controls, all lung recipients transplanted from donors after brain death (DBD) were considered. The primary outcomes were lung recipient 3-month, 1-year, and 5-year survival. A total of 269 LT were performed (60 cDCD and 209 DBD). There was no difference in survival at 3 months (98.3% cDCD vs. 93.7% DBD), 1 year (90.9% vs. 87.2%), and 5 years (68.7% vs. 69%). LT from the cDCD group had a higher rate of primary graft dysfunction grade 3 at 72 h (10% vs. 3.4%; p < .001). This is the largest experience ever reported with the use of A-NRP combined with lung retrieval in cDCD donors. This combined method is safe for lung grafts presenting short-term survival outcomes equivalent to those transplanted through DBD.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Mora V., Ballesteros M.A., Naranjo S., Sánchez L., Suberviola B., Iturbe D., Cimadevilla B., Tello S., Alvarez C., Miñambres E.,

 Fuente: Am J Transplant . 2022 Jul;22(7):1852-1860

Editorial: Wiley Periodicals Inc.

 Año de publicación: 2022

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/ajt.17057

ISSN: 1600-6135,1600-6143

Url de la publicación: https://www.doi.org/10.1111/ajt.17057

Autores/as

MORA, VICTOR

BALLESTEROS, MARIA ANGELES

NARANJO, SARA

SÁNCHEZ, LAURA

SUBERVIOLA, BORJA

ITURBE, DAVID

CIMADEVILLA, BONIFACIO

TELLO, SANDRA

ALVAREZ, CARLOS