Estamos realizando la búsqueda. Por favor, espere...
1579
37
170
28929
4401
2598
347
381
Abstract: Modulation of TCR signaling upon ligand binding is achieved by changes in the equilibrium between TCR degradation, recycling and synthesis; surprisingly, the molecular mechanism of such an important process is not fully understood. Here, we describe the role of a new player in the mediation of TCR degradation: the endocytic adaptor Numb. Our data show that Numb inhibition leads to abnormal intracellular distribution and defective TCR degradation in mature T lymphocytes. In addition, we find that Numb simultaneously binds to both Cbl and a site within CD3e that overlaps with the Nck binding site. As a result, Cbl couples specifically to the CD3e chain to mediate TCR degradation. The present study unveils a novel role of Numb that lies at the heart of TCR signaling initiation and termination
Fuente: International Immunology, 2016, 28(3), 127-137
Editorial: Oxford University Press
Año de publicación: 2015
Nº de páginas: 11
Tipo de publicación: Artículo de Revista
DOI: 10.1093/intimm/dxv060
ISSN: 0953-8178,1460-2377
Url de la publicación: https://doi.org/10.1093/intimm/dxv060
Leer publicación
MARTÍN BLANCO, NADIA
JIMÉNEZ TEJA, DANIEL
GABRIEL BRETONES SANCHEZ
BORROTO, ALDO
CARABALLO, MICHAEL
SCREPANTI, ISABELLA
JAVIER LEON SERRANO
ALARCÓN, BALBINO
CANELLES, MATILDE
Volver