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 Detalle_Publicacion

Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?

Abstract: Objective: SLE can affect any part of the gastrointestinal (GI) tract. GI symptoms are reported to occur in >50% of SLE patients. To describe the GI manifestations of SLE in the RELESSER (Registry of SLE Patients of the Spanish Society of Rheumatology) cohort and to determine whether these are associated with a more severe disease, damage accrual and a worse prognosis. Methods: We conducted a nationwide, retrospective, multicentre, cross-sectional cohort study of 3658 SLE patients who fulfil ?4 ACR-97 criteria. Data on demographics, disease characteristics, activity (SLEDAI-2K or BILAG), damage (SLICC/ACR/DI) and therapies were collected. Demographic and clinical characteristics were compared between lupus patients with and without GI damage to establish whether GI damage is associated with a more severe disease. Results: From 3654 lupus patients, 3.7% developed GI damage. Patients in this group (group 1) were older, they had longer disease duration, and were more likely to have vasculitis, renal disease and serositis than patients without GI damage (group 2). Hospitalizations and mortality were significantly higher in group 1. Patients in group 1 had higher modified SDI (SLICC Damage Index). The presence of oral ulcers reduced the risk of developing damage in 33% of patients. Conclusion: Having GI damage is associated with a worse prognosis. Patients on a high dose of glucocorticoids are at higher risk of developing GI damage which reinforces the strategy of minimizing glucocorticoids. Oral ulcers appear to decrease the risk of GI damage.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Rheumatology (Oxford) . 2021 Nov 3;60(11):5329-5336

Editorial: Oxford University Press

 Fecha de publicación: 03/11/2021

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1093/rheumatology/keab401

ISSN: 1462-0324,1462-0332

Url de la publicación: https://www.doi.org/10.1093/rheumatology/keab401

Autoría

TEJERA SEGURA, BEATRIZ

ALTABÁS GONZÁLEZ, IRENE

RÚA-FIGUEROA, IÑIGO

PÉREZ VEIGA, NATALIA

DEL CAMPO PÉREZ, VICTOR

OLIVÉ-MARQUÉS, ALEJANDRO

GALINDO, MARÍA

CALVO, JAIME

OVALLES-BONILLA, JUAN GABRIEL

FERNÁNDEZ-NEBRO, ANTONIO

MENOR-ALMAGRO, RAÚL

TOMERO, EVA

DEL VAL DEL AMO, NATIVIDAD

URIARTE ISACELAYA, ESTHER

BOTEANU, ALINA

NARVÁEZ, JAVIER

MOVASAT, ATUSA

MONTILLA, CARLOS