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Treatment with low-dose prednisone in refractory obstetric antiphospholipid syndrome: a retrospective cohort study and meta-analysis

Abstract: Background: Glucocorticoids have been suggested as a potential therapy in refractory obstetric antiphospholipid syndrome (oAPS). Our aims were to describe a cohort of patients with oAPS treated with low-dose glucocorticoids and to perform a systematic review and meta-analysis evaluating the effects of additional glucocorticoids on the pregnancy outcomes in oAPS patients. Methods: Retrospective study that included 11 women diagnosed with primary antiphospholipid syndrome. The meta-analysis was conducted by fitting random effects models and was checked for heterogeneity. Results: All women had suffered from early pregnancy losses and two also had a history of fetal deaths. We studied 47 pregnancies that resulted in 32 abortions (68.1%) and 3 fetal deaths (6.4%). Twenty-six pregnancies were under treatment, mainly LDA and LMWH. Low-dose glucocorticoids were indicated in 13 pregnancies (always in association with LDA and LMWH). There was a decrease in pregnancy loss in those patients treated with LDA and LMWH. Treatment with glucocorticoids significantly increased the rate of successful pregnancy (38.5% abortions in treated vs 85.3% abortions in non-treated pregnancies; p=0.003). After multivariate GEE analysis, only glucocorticoids remained inversely associated with pregnancy loss (OR=0.157, (CI 0.025-0.968, p=0.046)). The meta-analysis showed that glucocorticoids tended to improve the frequency of successful pregnancy (OR= 0.509 (0.252-1.028), p=0.06). Three cases of gestational diabetes and one of preeclampsia were observed in our cohort. The meta-analysis, which mostly included studies using high-dose steroids, showed that glucocorticoids increased not only the frequency of preeclampsia and gestational diabetes, but also the rate of pre-term birth. Conclusions: The efficacy of low-dose glucocorticoids in addition to the standard therapy in patients with refractory oAPS should be confirmed in well-designed clinical trials. However, high doses of steroids significantly increase the frequency of maternal and fetal morbidities, making their use strongly inadvisable.

 Autoría: Riancho-Zarrabeitia L., Lopez-Marin L., Cacho P.M., López-Hoyos M., Barrio R.d., Haya A., Martínez-Taboada V.M.,

 Fuente: Lupus, 2022, 31(7), 808-819

Editorial: SAGE Publications

 Año de publicación: 2022

Nº de páginas: 12

Tipo de publicación: Artículo de Revista

 DOI: 10.1177/09612033221091401

ISSN: 0961-2033,1477-0962

Url de la publicación: https://www.doi.org/10.1177/09612033221091401

Autoría

LEYRE RIANCHO ZARRABEITIA

LOPEZ-MARIN, LAURA

MUÑOZ CACHO, PEDRO

BARRIO, RAFAEL DEL

HAYA, ANA