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Abstract: Objective: This study aimed to investigate the effectiveness and safety of single and repeated courses of rituximab in patients with refractory lupus. Methods: LESIMAB is a multicenter, retrospective, longitudinal study of lupus patients who have not responded to standard therapy and have been treated with rituximab. Response rates at six months and at follow-up were defined as efficacy outcomes. Complete response was defined as a SELENA-SLEDAI score???two and a SELENA-SLEDAI Flare Index of zero. Partial response was defined as a reduction in the SELENA-SLEDAI score of ?four points with no new or worsening of symptoms. Adverse events were collected. Results: Seventy-three (62.9%) of 116 patients achieved a response at six months (complete in 22 and partial in 51). Ninety-seven (77.6%) of 128 patients achieved a response after a mean follow-up of 20.0?±?15.2 months (complete in 50 and partial in 47). High baseline SLEDAI score, previous treatment with ?100?mg/day prednisone, and no history of severe hematologic flare were associated with response after the first treatment course. The median time to response was 6.5 months (95% CI, 5.0?8.0). Thirty-seven patients (38.1%) relapsed after the first infusion. The flare was severe in seven cases and mild to moderate in 29 cases. Serious infection rate was 12.6/100 patient-years. A schedule of four weekly doses was associated with more serious infections. Six patients died: two of infection and four of lupus complications. Conclusion: Rituximab can be an effective treatment option for patients who have refractory lupus with severe or life-threatening disease with an acceptable tolerance profile.
Fuente: Lupus, 2012, 21(10), 1063-1076
Editorial: SAGE Publications
Año de publicación: 2012
Tipo de publicación: Artículo de Revista
DOI: 10.1177/0961203312446627
ISSN: 0961-2033,1477-0962
Url de la publicación: https://doi.org/10.1177/0961203312446627
Leer publicación
FERNÁNDEZ-NEBRO, A.
MARENCO DE LA FUENTE, J. L.
CARREÑO, L.
GALINDO IZQUIERDO, M.
TOMERO, E.
RÚA-FIGUEROA, I.
HERNÁNDEZ-CRUZ, B.E.
NARVÁEZ, J.
ÚCAR, E.
OLIVÉ, A.
ZEA, A.
FERNÁNDEZ-CASTRO, M.
RAYA-ÁLVAREZ, E.
PEGO-REIGOSA, J.M.
FREIRE, M.
VICTOR MANUEL MARTINEZ TABOADA
PÉREZ-VENEGAS, J.
SÁNCHEZ-ATRIO, A.I.
VILLA-BLANCO, I.
MANRIQUE-ARIJA, S.
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